SREBF1 Antikörper (pSer439)

Produktnummer ABIN2568461

Produktdetails anti-SREBF1 Antikörper

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Bindungsspezifität: pSer439

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SREBF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects endogenous level of SREBP-1 only when phosphorylated at serine 439.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: SREBP-1 (phospho Ser439) antibody was raised against a peptide sequence around phosphorylation site of serine439 (Q-S-S (p)-P-L) derived from Human SREBP-1 .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu SREBF1

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Andere Bezeichnung: SREBP-1 (SREBF1 Produkte)

Synonyme: SREBP-1c antikoerper, SREBP1 antikoerper, bHLHd1 antikoerper, ADD-1 antikoerper, ADD1 antikoerper, D630008H06 antikoerper, SREBP-1 antikoerper, SREBP-1a antikoerper, SREBP1c antikoerper, Srebp1 antikoerper, SCREBP1 antikoerper, SREBP-1C antikoerper, SREBF1 antikoerper, srebp1 antikoerper, sterol regulatory element binding transcription factor 1 antikoerper, sterol regulatory element binding transcription factor 1 L homeolog antikoerper, sterol regulatory element binding protein-1 antikoerper, Sterol regulatory element Binding Protein antikoerper, SREBF1 antikoerper, Srebf1 antikoerper, srebf1.L antikoerper, SREBP-1 antikoerper, srebf1 antikoerper, sbp-1 antikoerper

Hintergrund: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

Molekulargewicht: 122 kDa

Gen-ID: 6720

NCBI Accession: NP_001005291

UniProt: P36956

Pathways: AMPK Signaling, Caspase Kaskade in der Apoptose, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha