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SREBF1 Antikörper (AA 349-378)
SREBF1
Reaktivität: Human
WB, IHC (p), FACS
Wirt: Kaninchen
Polyclonal
RB21265
unconjugated
Produktdetails anti-SREBF1 Antikörper
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Target
Alle SREBF1 Antikörper anzeigen
SREBF1
(Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
Bindungsspezifität
Alle Epitope für SREBF1 Antikörper
AA 349-378
Reaktivität
Alle Reaktivitäten für SREBF1 Antikörper
Human
Wirt
Alle Wirte für SREBF1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für SREBF1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für SREBF1 Antikörper
Dieser SREBF1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für SREBF1 Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
Homologie
Ha, M, Rat
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SREBF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-378 amino acids of human SREBF1.
Klon
RB21265
Isotyp
IgG
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Anwendungsinformationen
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Applikationshinweise
WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Details zu SREBF1
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Target
SREBF1
(Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
Andere Bezeichnung
SREBF1 (SREBF1 Produkte )
Synonyme
SREBP-1c antikoerper, SREBP1 antikoerper, bHLHd1 antikoerper, ADD-1 antikoerper, ADD1 antikoerper, D630008H06 antikoerper, SREBP-1 antikoerper, SREBP-1a antikoerper, SREBP1c antikoerper, Srebp1 antikoerper, SCREBP1 antikoerper, SREBP-1C antikoerper, SREBF1 antikoerper, srebp1 antikoerper, sterol regulatory element binding transcription factor 1 antikoerper, sterol regulatory element binding transcription factor 1 L homeolog antikoerper, sterol regulatory element binding protein-1 antikoerper, Sterol regulatory element Binding Protein antikoerper, SREBF1 antikoerper, Srebf1 antikoerper, srebf1.L antikoerper, SREBP-1 antikoerper, srebf1 antikoerper, sbp-1 antikoerper
Hintergrund
SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.
Molekulargewicht
121675
Gen-ID
6720
NCBI Accession
NP_001005291 , NP_004167
UniProt
P36956
Pathways
AMPK Signaling , Caspase Kaskade in der Apoptose , Negative Regulation of Hormone Secretion , Regulation of Lipid Metabolism by PPARalpha
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