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GSK3 alpha Antikörper (truncated)
GSK3a
Reaktivität: Human
WB, ELISA
Wirt: Maus
Monoclonal
6G12C2
unconjugated
Produktnummer ABIN2464060
Produktdetails anti-GSK3 alpha Antikörper
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Target
Alle GSK3 alpha (GSK3a) Antikörper anzeigen
GSK3 alpha (GSK3a)
(Glycogen Synthase Kinase 3 alpha (GSK3a))
Bindungsspezifität
Alle Epitope für GSK3 alpha Antikörper
truncated
Reaktivität
Alle Reaktivitäten für GSK3 alpha Antikörper
Human
Wirt
Alle Wirte für GSK3 alpha Antikörper
Maus
Klonalität
Alle Klonalitäten für GSK3 alpha Antikörper
Monoklonal
Konjugat
Alle Konjugate für GSK3 alpha Antikörper
Dieser GSK3 alpha Antikörper ist unkonjugiert
Applikation
Alle Applikationen für GSK3 alpha Antikörper
Western Blotting (WB), ELISA
Immunogen
Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3).
Klon
6G12C2
Isotyp
IgG1
Top Product
Discover our top product GSK3a Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Western Blot:1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
(ausblenden)
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Lagerung
-20 °C
Informationen zur Lagerung
GSK3 alpha monoclonal antibody can be stored at -20 °C, stable for one year.
Details zu GSK3 alpha
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Target
GSK3 alpha (GSK3a)
(Glycogen Synthase Kinase 3 alpha (GSK3a))
Andere Bezeichnung
GSK3alpha (GSK3a Produkte )
Synonyme
2700086H06Rik antikoerper, GSK3A antikoerper, GSK-3[a] antikoerper, GSK-3[b] antikoerper, GSK3 antikoerper, gsk3a antikoerper, xgsk3 antikoerper, glycogen synthase kinase 3 alpha antikoerper, glycogen synthase kinase 3 alpha b antikoerper, glycogen synthase kinase 3 alpha S homeolog antikoerper, GSK3A antikoerper, Gsk3a antikoerper, gsk3a antikoerper, gsk3ab antikoerper, gsk3a.S antikoerper, Bm1_31380 antikoerper
Hintergrund
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily?GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97 % sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Gen-ID
2931
UniProt
P49840
Pathways
PI3K-Akt Signalweg , WNT Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , cAMP Metabolic Process , Cellular Glucan Metabolic Process , Regulation of Muscle Cell Differentiation , Regulation of G-Protein Coupled Receptor Protein Signaling , ER-Nucleus Signaling , Regulation of Carbohydrate Metabolic Process , BCR Signaling , Warburg Effekt
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