BCL10 Antikörper

Produktnummer ABIN2464015

Produktdetails anti-BCL10 Antikörper

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCL10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Antibody is purified by protein A affinity chromatography.

Immunogen: Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3).

Klon: 4F8E8H8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IHC(P):Dilution 1:1,000 - 1:2,000
IHC(F):Dilution 1:1,000 - 1:2,000
Western blot:Dilution 1:2,000 - 1:5,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: -20 °C

Informationen zur Lagerung: BCL-10 monoclonal antibody can be stored at -20 °C, stable for one year.

Details zu BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Andere Bezeichnung: BCL10 (BCL10 Produkte)

Synonyme: CARMEN antikoerper, CIPER antikoerper, CLAP antikoerper, c-E10 antikoerper, mE10 antikoerper, BCL10 antikoerper, AI132454 antikoerper, BCL-10 antikoerper, C81403 antikoerper, ME10 antikoerper, cE10 antikoerper, bcl10 antikoerper, B-cell CLL/lymphoma 10 antikoerper, B-cell lymphoma/leukemia 10-like antikoerper, B cell leukemia/lymphoma 10 antikoerper, B-cell lymphoma/leukemia 10 antikoerper, BCL10 antikoerper, Bcl10 antikoerper, bcl10 antikoerper, LOC100223183 antikoerper

Hintergrund: B-cell CLL/lymphoma 10, also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-κ,B. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-κ,B signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-κ,B, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Gen-ID: 8915

UniProt: O95999

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine