BCL10 Antikörper (N-Term)

Produktnummer ABIN1888191

Produktdetails anti-BCL10 Antikörper

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids near the amino terminus of human Bcl10.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Andere Bezeichnung: Bcl-10 (BCL10 Produkte)

Synonyme: CARMEN antikoerper, CIPER antikoerper, CLAP antikoerper, c-E10 antikoerper, mE10 antikoerper, BCL10 antikoerper, AI132454 antikoerper, BCL-10 antikoerper, C81403 antikoerper, ME10 antikoerper, cE10 antikoerper, bcl10 antikoerper, B-cell CLL/lymphoma 10 antikoerper, B-cell lymphoma/leukemia 10-like antikoerper, B cell leukemia/lymphoma 10 antikoerper, B-cell lymphoma/leukemia 10 antikoerper, BCL10 antikoerper, Bcl10 antikoerper, bcl10 antikoerper, LOC100223183 antikoerper

Hintergrund: Apoptosis is related to many diseases including cancer.Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases.CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2.A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP.Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene.Overexpression of Bcl10 induces JNK, p38, and NF-kappaB activation.Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation.Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy.Bcl10 is expressed in many human and murine tissues and cell lines.
Synonyms: CIPER, CLAP

Molekulargewicht: 31 kDa

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine