CD40 Antikörper
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- Target Alle CD40 Antikörper anzeigen
- CD40
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD40 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS)
- Marke
- BD Pharmingen™
- Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Sterilität
- 0.2 μm filtered
- Endotoxin-Niveau
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- Klon
- 5C3
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product CD40 Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.0 mg/mL
- Buffer
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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CD40 is functionally expressed on human thymic epithelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 775-82, (1992) (PubMed).
: "The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis." in: Cell, Vol. 66, Issue 2, pp. 233-43, (1991) (PubMed).
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CD40 is functionally expressed on human thymic epithelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 775-82, (1992) (PubMed).
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- Target
- CD40
- Andere Bezeichnung
- CD40 (CD40 Produkte)
- Synonyme
- Bp50 antikoerper, CDW40 antikoerper, TNFRSF5 antikoerper, p50 antikoerper, AI326936 antikoerper, GP39 antikoerper, HIGM1 antikoerper, IGM antikoerper, IMD3 antikoerper, T-BAM antikoerper, TRAP antikoerper, Tnfrsf5 antikoerper, TNFSF5 antikoerper, CD40 molecule antikoerper, CD40 antigen antikoerper, CD40 antikoerper, Cd40 antikoerper
- Hintergrund
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This 5C3 monoclonal antibody specifically binds to CD40, a 45-48 kDa type I integral membrane glycoprotein. CD40 is expressed on B lymphocytes, but is not expressed on terminally differentiated B cells. CD40 is also expressed by endothelial cells, basal epithelial cells and some epithelial cell carcinomas, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, and CD34+ hematopoietic progenitor cells. This antibody is useful for studying the roles played by CD40 in B-cell growth, proliferation, and differentiation including immunoglobulin isotype switching. Anti-CD40 antibodies have been reported to stimulate B-cell proliferation when costimulated with anti-µ, anti-CD20 antibodies or with phorbol esters. 5C3 is capable of inducing B-cell proliferation when presented with IL-4.
Synonyms: TNFRSF5, TNF receptor superfamily member 5, CD40L receptor, Bp50, p50 - Pathways
- NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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