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The protein encoded by CACNG8 is a type I transmembrane AMPA receptor regulatory protein (TARP).
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These results indicate that CACNG4 (zeige CACNG4 Antikörper), CACNG5 (zeige CACNG5 Antikörper), CACNG6 (zeige CACNG6 Antikörper) and CACNG8 may contribute to the risk of SCZ. The statistical epistasis identified between CACNG5 (zeige CACNG5 Antikörper) and CACNG6 (zeige CACNG6 Antikörper) suggests that there may be an underlying biological interaction between the two genes.
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 (zeige KCNN3 Antikörper) and KCNJ2 (zeige KCNJ2 Antikörper) Genes and CACNG8-Linked Left Ventricular Dysfunction
Critically, by altering the two interacting loops of TARP (zeige TINAGL1 Antikörper) gamma2 and TARP (zeige TINAGL1 Antikörper) gamma8, the authors could entirely remove all allosteric modulation of GluA2 (zeige GRIA2 Antikörper), without affecting formation of AMPA (zeige GRIA3 Antikörper) receptor-TARP (zeige TINAGL1 Antikörper) complexes.
these findings demonstrate that TARPgamma-8 is a crucial mediator of CaMKII (zeige CAMK2G Antikörper)-dependent Long Term Potentiation and therefore a molecular target that controls synaptic plasticity and associated cognitive functions.
TARP gamma-8 is the only TARP (zeige TINAGL1 Antikörper) expressed at nonperforated type of pyramidal cell synapses, playing an essential role in low-density or basal AMPAR expression
This study demonstrated that genetic inactivation of this specific population of AMPA (zeige GRIA3 Antikörper) receptors results in modest changes in behavior characterized by a mild hyperactivity.
coexpression of both auxiliary subunits,CKAMP44 (zeige Shisa9 Antikörper) and TARP gamma-8 is necessary for the efficient targeting of AMPARs to the cell surface of dentate gyrus granule cells
The results of thia study suggested that there are distinct TARP (zeige TINAGL1 Antikörper)-dependent mechanisms for synaptic transmission and long term potential.
Tarp gamma-8 (and CNIH-2 (zeige CNIH2 Antikörper)) functionally interact with common AMPA (zeige GRIA3 Antikörper) receptor complexes in hippocampus; however, TARP gamma-8-containing hippocampal neurons do not display resensitization.
Previously uncharacterized roles for the TARP (zeige TINAGL1 Antikörper) intracellular N terminus, loop, and C terminus in modulating both the trafficking and gating of synaptic AMPARs, are reported.
Discusses evidence for non-AUG translation start codon for Cacng8.
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon.
calcium channel, voltage-dependent, gamma subunit 8
, voltage-dependent calcium channel gamma-8 subunit
, TARP gamma-8
, neuronal voltage-gated calcium channel gamma-8 subunit
, transmembrane AMPAR regulatory protein gamma-8
, TARP gamma 8