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anti-Human WT1 Antikörper:
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Human Monoclonal WT1 Primary Antibody für IHC, IHC (fro) - ABIN258719
Rauscher, Morris, Fredericks, Lopez-Guisa, Balakrishnan, Jost, Herlyn, Rodeck: Characterization of monoclonal antibodies directed to the amino-terminus of the WT1, Wilms' tumor suppressor protein. in Hybridoma 1998
Show all 4 Pubmed References
Human Polyclonal WT1 Primary Antibody für CyTOF, FACS - ABIN4899232
Da Sacco, Lemley, Sedrakyan, Zanusso, Petrosyan, Peti-Peterdi, Burford, De Filippo, Perin: A novel source of cultured podocytes. in PLoS ONE 2013
Show all 2 Pubmed References
Human Polyclonal WT1 Primary Antibody für ELISA, WB - ABIN188555
Rao, Pham, Imam, MacLean, Murali, Furuta, Sinha-Hikim, Wilkinson: Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. in Genes & development 2006
Human Monoclonal WT1 Primary Antibody für FACS, IF - ABIN5590995
Rauscher: The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993
Multiple studies provide evidence that WT1 plays a significant role in a variety of cancers occurring mainly in childhood and adolescence, but with involvement in some adult cancers. Also, Wt1 has a tumor suppressive function and oncogenic properties as well.
Study highlighted the importance of WT1 mutations in developmental renal disorders and showed that novel genetic technologies, particularly rapid sequencing techniques, have allowed the identification of far more WT1 mutations, relevant to clinical practice, and thus highlighting the range of WT1 disease and variable phenotype-genotype correlation.
Study reviews the dynamic expression pattern of WT1 gene during embryonic development and its many functions in the regulation of the expression of target genes acting in tissue development, growth, differentiation, and apoptosis. [review]
correlation between relapse and MRD(WT1) was stronger in blood than in bone marrow samples
WT1 overexpression is associated with minimal residual disease in acute myeloid leukemia (zeige BCL11A Antikörper).
WT1 expression status represents a good molecular marker of prognosis, response to treatment, and minimal residual disease monitoring in acute myeloid leukemia (zeige BCL11A Antikörper) with normal karyotype
Review/Meta-analysis: WT1 rs16754 polymorphism is associated with better survival in acute myeloid leukemia (zeige BCL11A Antikörper).
we report that CUG initiation site for WT1 protein synthesis (CUG)-translated WT1 (cugWT1), an N-terminally extended form of canonical AUG initiation site for WT1 protein synthesis (AUG)-translated WT1 (augWT1), was overexpressed in most cancer cell lines and cancer tissues and functioned as an oncogene (zeige RAB1A Antikörper)
Furthermore, chromatin immunoprecipitation assays revealed that COL4A1 (zeige COL4A1 Antikörper) and WNT4 (zeige WNT4 Antikörper) promoter is directly bound by wild-type WT1 protein, but not the p.F435L WT1 variant. Thus, we identified a novel functional variant of WT1 functionally associated with idiopathic non-obstructive azoospermia.
Data reveal that MiR (zeige MLXIP Antikörper)-193a directly targets WT1 and indirectly modulates E-cadherin (zeige CDH1 Antikörper) and that overexpression of WT1 partially prevents miR (zeige MLXIP Antikörper)-193a-induced inhibition of migration and invasion of non-small cell lung cancers, suggesting that WT1 plays an important role in the anti-metastasis by miR (zeige MLXIP Antikörper)-193a.
WT1 interference with Wnt (zeige WNT2 Antikörper) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
Study summarizes the different roles of WT1b gene in the embryonic zebrafish kidney and the adult kidney as well. [review]
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
both the local oxygen environment and WT1, which enhances KDR (zeige KDR Antikörper) expression, contribute to sex-specific Sox9 (zeige SOX9 Antikörper) expression in developing murine gonads
The authors show that the posthepatic mesenchymal plate coelomic epithelium gives rise to a mesenchyme that populates the pleuroperitoneal folds isolating the pleural cavities before the migration of the somitic myoblasts. This process fails when Wt1 is deleted from this area.
Study reveals a novel role for Wt1 in early mammalian development and identifies proteases as critical mediators of the maternal-embryonic interaction. Data also suggest that the role of Wt1 in regulating fertility is conserved in mammals.
WT1 is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (zeige SF1 Antikörper) expression. Without Wt1, the expression of Sf1 (zeige SF1 Antikörper) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
study provides novel insights into the role of WT1 and GATA4 (zeige GATA4 Antikörper) during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development
WT1 regulates reporter gene expression through interaction with 3' UTR (zeige UTS2R Antikörper)-binding sites
These results indicate that Osr1 (zeige OSR1 Antikörper) and Wt1 act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Wt1 regulates the development of FLC.
WT1 stimulates IGFBP5 (zeige IGFBP5 Antikörper) transcription in developing murine kidney.
Over expression of miR (zeige MLXIP Antikörper)-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for Focal segmental glomerulosclerosis and miR (zeige MLXIP Antikörper)-206 may be a potential therapeutic target.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Wilms tumor protein
, amino-terminal domain of EWS
, last three zinc fingers of the DNA-binding domain of WT1
, Chick Wilm's tumour protein
, Wilms tumor 1
, Wilms tumor protein homolog A
, Wilms tumor protein homolog
, Wilms tumor suppressor protein 1b
, Wilm's tumor suppressor
, Wilms tumor protein homolog B