WT1 Produkte
(Wilms Tumor 1 (WT1))
Kategorien
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010].
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Ausgewählte WT1 Kategorien
WT1 Antikörper
High quality antibodies with extensive validation data.
WT1 ELISA Kits
Reliable ELISA kits for a wide range of species.
WT1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene WT1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Monkey
Applikation
FACS, IHC, WB, ELISA, ICC
Validierungen
- (8)
Kat. Nr.
ABIN7193614
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (1)
- (5)
Kat. Nr.
ABIN3021698
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
IF, FACS, WB, IHC (p)
Validierungen
- (5)
Kat. Nr.
ABIN655904
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene WT1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6971178
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960529
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN5592787
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene WT1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (2)
Kat. Nr.
ABIN3075507
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125729
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1325392
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren WT1 Produkten
: "Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis." in: Disease models & mechanisms, Vol. 14, Issue 6, (2022) (PubMed).: "Nuclear paraspeckle assembly transcript 1 promotes the podocyte injury via targeting miR-23b-3p/B-cell lymphoma-2 interacting protein 3 like axis." in: Renal failure, Vol. 44, Issue 1, pp. 1961-1975, (2022) (PubMed).
: "Differentiation of human iPSCs into functional podocytes." in: PLoS ONE, Vol. 13, Issue 9, pp. e0203869, (2019) (PubMed).
: "Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression." in: Ultrastructural pathology, Vol. 42, Issue 5, pp. 430-439, (2018) (PubMed).
: "Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease." in: Diabetes, Vol. 67, Issue 11, pp. 2420-2433, (2018) (PubMed).
: "A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)." in: International journal of cancer, Vol. 136, Issue 7, pp. 1546-58, (2015) (PubMed).
: "Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells." in: PLoS ONE, Vol. 10, Issue 3, pp. e0119837, (2015) (PubMed).
: "Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury." in: Scientific reports, Vol. 5, pp. 8826, (2015) (PubMed).
: "BAMBI elimination enhances alternative TGF-β signaling and glomerular dysfunction in diabetic mice." in: Diabetes, Vol. 64, Issue 6, pp. 2220-33, (2015) (PubMed).
: "Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice." in: Molecular and cellular biochemistry, Vol. 394, Issue 1-2, pp. 145-54, (2014) (PubMed).
Synonyme und alternative Namen zu WT1
Wilms tumor 1 (WT1), Wilms tumor 1 S homeolog (wt1.S), Wilms tumor 1 (wt1), wilms tumor 1b (wt1b), Wilms tumor 1 (Wt1), Wilms tumor protein (wt1), Wilms tumor 1 homolog (Wt1), Wilms tumor 1 L homeolog (wt1.L), AWT1, CWT1, D630046I19Rik, EWS-WT1, GUD, gud, NPHS4, si:ch211-160j6.3, WAGR, wagr, WIT-2, wit-2, wt-1, WT-1, Wt-1, WT1, wt1, WT33, wt33, XeWT1, xWT1, xwt1, XWT1a, XWT1b, zgc:152697Bezeichner auf Proteinebene für WT1
- Wilms tumor protein
- amino-terminal domain of EWS
- last three zinc fingers of the DNA-binding domain of WT1
- Chick Wilm's tumour protein
- Wilms tumor 1
- Wilms tumor protein homolog A
- Wilms tumor protein homolog
- Wilms tumor suppressor protein 1b
- Wilm's tumor suppressor
- Wilms tumor protein homolog B
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