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The Tim-3/Gal-9 (zeige LGALS9 Proteine) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
the CD4 (zeige CD4 Proteine)(+)CD25 (zeige IL2RA Proteine)(+)Foxp3 (zeige FOXP3 Proteine)(+) Treg cells from RA patients demonstrated a reduction of Tim3 and were less functional than Treg cells from healthy controls in a Tim3-related manner.
our study highlights the role of TIM-3 as a potential prognostic marker and a promising therapeutic target in solid tumors.
HAVCR2 regulates cytokines, chemokines, prostaglandins and cell adhesion molecules in the presence of viral infection, which suggests a potential for HAVCR2 activators as therapeutics for the management of preterm birth associated with viral infections.
Preoperative Tim3 expression on peripheral NK cells is correlated with differential staging in colorectal cancer, and may be useful as a serum biomarker.
TIM-3 polymorphism is associated with response to therapy in hepatitis B virus-related hepatocellular carcinoma.
BMI-1 (zeige BMI1 Proteine), TIM-3 and CLL-1 (zeige COLEC10 Proteine) have roles in acute myeloid leukemia (zeige BCL11A Proteine) prognosis and therapy
Quantification of TIM-3 and KIM-1 (zeige HAVCR1 Proteine) mRNA expressions, along with KIM-1 (zeige HAVCR1 Proteine) protein measurements in urine and blood could be employed as promising tools for noninvasive diagnosis of allograft dysfunction.
Results show that human acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) cells possess a secretory pathway which leads to the production and release of soluble Tim-3 and galectin-9 (zeige LGALS9 Proteine). Both proteins prevent the activation of NK cells and impair their AML (zeige RUNX1 Proteine) cell-killing activity.
after 14 days of glucocorticoid therapy, clinical findings (serum bilirubin, skin GVHD) and plasma biomarkers (TIM3, ST2, sTNFR1) can predict failure of GVHD treatment and nonrelapse mortality.
These findings suggested that rs10053538 in TIM-3 might increase susceptibility to and promote the progression of breast cancer in Chinese women
CB2R (zeige CNR2 Proteine) may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1alpha (zeige HIF1A Proteine)/TIM-3 signalling pathway in microglia
Our results show that Tim-3 is a critical negative regulator of NLRP3 (zeige NLRP3 Proteine) inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
demonstrated that both IL-10 (zeige IL10 Proteine) and TGF-beta (zeige TGFB1 Proteine) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (zeige SRC Proteine) and Bruton's tyrosine kinase (zeige BTK Proteine)
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (zeige HDAC3 Proteine)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (zeige HDAC3 Proteine)-induced chronic allergic airway inflammation.
Authors found that a CD8 (zeige CD8A Proteine)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (zeige TIMD4 Proteine) binds TIM3 on the surface of polarized Th1 (zeige HAND1 Proteine) cells to induce Th1 (zeige HAND1 Proteine) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (zeige LGALS9 Proteine)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (zeige LYN Proteine) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (zeige FCER1A Proteine) ligation.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog