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Cow (Bovine) Monoclonal ARNT Primary Antibody für ChIP, GS - ABIN151055
Alam, Maizels, Park, Ghaey, Feiger, Chandel, Hunzicker-Dunn et al.: Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is ... in The Journal of biological chemistry 2004
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Cow (Bovine) Polyclonal ARNT Primary Antibody für ChIP, GS - ABIN151037
Sulentic, Holsapple, Kaminski: Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway. in The Journal of pharmacology and experimental therapeutics 2000
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Amphibian Monoclonal ARNT Primary Antibody für GS, ICC - ABIN152684
Singh, Wyman, Casado, Garrett, Gasiewicz: Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells. in Carcinogenesis 2009
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Cow (Bovine) Polyclonal ARNT Primary Antibody für WB - ABIN2777195
Kurlak, Mistry, Cindrova-Davies, Burton, Broughton Pipkin: Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. in The Journal of physiology 2016
Human Polyclonal ARNT Primary Antibody für IF, WB - ABIN513506
Miranda, Nordgren, Male, Lawrence, Hoakwie, Cuda, Court, Fox, Townsend, Packham, Eccles, Tavassoli: A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. in Journal of the American Chemical Society 2013
Human Monoclonal ARNT Primary Antibody für FACS, IF - ABIN2722724
Hao, Bhakti, Peet, Whitelaw: Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. in Nucleic acids research 2013
in transcriptionally active heterodimer with AHR (zeige AHR Antikörper), which recognizes the dioxin response element (DRE (zeige SUFUH Antikörper)) in the promoter of downstream genes, right next to the DRE (zeige SUFUH Antikörper)-docking sites is the extensive dimerization surface that is more hydrophobic than other surface areas, indicating that the dimerization interface of the AHR (zeige AHR Antikörper) transcription complex is largely dictated by hydrophobic contacts
Here the authors examined the crystal structures of multi-domain NPAS1 (zeige NPAS1 Antikörper)-ARNT and NPAS3 (zeige NPAS3 Antikörper)-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets.
Findings reveal that certain blood cancers rely on ARNT isoform 1 to potentiate proliferation by antagonizing RelB (zeige RELB Antikörper) and p53 (zeige TP53 Antikörper)-dependent cell cycle arrest and apoptosis.
The structure clearly disclosed that AhRR (zeige CYP1A1 Antikörper) competitively represses AhR (zeige AHR Antikörper) binding to ARNT and target DNA and further suggested the existence of an AhRR (zeige CYP1A1 Antikörper)-ARNT-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR (zeige CYP1A1 Antikörper) represses AhR (zeige AHR Antikörper)-mediated gene transcription.
Study showed that polymorphism rs2228099 of the ARNT gene could be a novel susceptibility gene to essential hypertension.
The results revealed a HIF-1alpha (zeige HIF1A Antikörper)-dependent mechanism leading to ARNT upregulation in hypoxia.
The protein levels of phosphorylated (p)Akt, Erk1/2, pErk1/2, HIF1alpha and HIF1beta were significantly increased by 5.89, 0.5, 0.59, 1.46 and 0.92fold, respectively, in the patients with PAH, compared with those in the controls group
Report quinone-mediated induction of cytochrome P450 1A1 (zeige CYP1A1 Antikörper) in HepG2 cells through increased interaction of aryl hydrocarbon receptor (zeige AHR Antikörper) with aryl hydrocarbon receptor nuclear translocator.
this study shows that ARNT is upregulated in skin from atopic dermatitis patients in China
Data suggest that activation of the AhR (zeige AHR Antikörper)/ARNT (aryl hydrocarbon receptor/aryl hydrocarbon receptor (zeige AHR Antikörper) nuclear translocator) signaling by AhR (zeige AHR Antikörper) ligands (environmental carcinogens TCDD/3MC/PCB (zeige PC Antikörper) used here) represents novel mechanism for regulating the expression of ADH1B (alcohol dehydrogenase 1B (zeige ADH1B Antikörper)) and other isoenzymes (ADH4 (zeige ADH4 Antikörper), ADH6 (zeige ADH6 Antikörper)) in hepatocytes.
Results elucidate the dimerization process of AhR (zeige AHR Antikörper) with ARNT and propose the structure of the N-terminal region of the AhR:ARNT dimer including the bHLH, PAS (zeige PASK Antikörper)-A and PAS (zeige PASK Antikörper)-B domains.
results provide convincing evidence that reduced hepatic ARNT can contribute to inappropriate hepatic glucose production and post-prandial dyslipidaemia
These promoters possess potential signature sequences for common as well as different transcription factors suggesting complex regulation of Arnt gene.
The only in vivo defects found in beta-Arnt mice were significant increases in the respiratory exchange ratio and in vivo carbohydrate oxidation, and a decrease in lipid oxidation
hepatocyte ARNT is not a requirement for initiation of liver fibrogenesis, but does regulate pro-fibrotic gene expression and macrophage accumulation.
HIF-1beta hepatocyte-specific knockout mice had less liver injury and steatosis in response to Gao-binge ethanol treatment.
Candidate gene analysis focused on Arnt as an influence on circadian regulation in the 'drinking in the dark' phenotype of alcohol consumption.
crystal structures for each of mouse HIF-2alpha (zeige EPAS1 Antikörper)-ARNT and HIF-1alpha (zeige HIF1A Antikörper)-ARNT heterodimers in states that include bound small molecules and their hypoxia response element
We determined that ARNT is essential for adult and fetal hematopoietic stem cell viability and homeostasis.
ARNT is a critical regulator of myocardial fatty acid metabolism and its deletion leads to cardiomyopathy and an increase in triglyceride accumulation through PPARA (zeige PPARA Antikörper).
Morpholino experiments show that knockdown of ARNT1 offers protection from TCCD-induced cardiotoxicity.
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1\;12)(q21\;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.
class E basic helix-loop-helix protein 2
, dioxin receptor, nuclear translocator
, hypoxia-inducible factor 1, beta subunit
, ARNT protein
, HIF-1 beta
, aryl hydrocarbon receptor nuclear translocator
, hypoxia-inducible factor 1 beta
, hypoxia-inducible factor 1-beta
, Aryl hydrocarbon receptor nuclear translocator 1
, aryl hydrocarbon receptor nuclear translocater
, aryl hydrocarbon receptor nuclear translocator 2