TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
Protein-Typ
Recombinant
Proteineigenschaft
AA 52-212
Spezies
Human
Quelle
HEK-293T Cells
Aufreinigungstag / Konjugat
Dieses TNFRSF10B Protein ist gelabelt mit Fc Tag.
Applikation
ELISA
Spezifität
Binds human and mouse TRAIL. Other species not tested.
Produktmerkmale
Inhibits soluble TRAIL-induced apoptosis in a concentration range of 0.5-10 µg/mL. Concentrations of rhTRAIL-R2:Fc required to inhibit may vary depending on the cell type studied and on the concentration of sTRAIL used to kill cells. The extracellular domain (AA 52-212) of human TRAIL-R2 fused to the Fc portion of human IgG1.
TNFRSF10B
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ELISA
TRAIL receptors are members of the TNF family of proteins. TRAIL-R2 (DR5) is a 50 kDa transmembrane protein containing 2 cysteine- rich repeats in the extracellular portion and a cytoplasmic motif called a `death domain' (DD). Binding of TRAIL (APO-2L) to TRAIL-R2 can induce apoptosis. Other identified TRAIL receptors include TRAIL-R1 (DR4), which like TRAIL-R2 promotes apoptosis, and three receptors (TRAIL-R3, TRAIL-R4, and Osteoprotegerin) that are inhibitory. Synonyms: DR5, KILLER, TNFRSF 10B, CD262