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Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-182) (Active) protein (Fc Tag)

TNFRSF10B Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed (1 reference)
Produktnummer ABIN2181868
$286.00
Zzgl. Versandkosten $45.00
Lieferung in 11 Werktagen
  • Target Alle TNFRSF10B Proteine anzeigen
    TNFRSF10B
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 56-182
    Spezies
    • 25
    • 10
    • 2
    • 1
    Human
    Quelle
    • 13
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses TNFRSF10B Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 56-182
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.5 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM NaCl, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Mettler Izquierdo, Varela, Park, Collarini, Lu, Pramanick, Rucker, Lopalco, Etches, Harriman: "High-efficiency antibody discovery achieved with multiplexed microscopy." in: Microscopy (Oxford, England), Vol. 65, Issue 4, pp. 341-52, (2018) (PubMed).

  • Target
    TNFRSF10B
    Andere Bezeichnung
    TRAIL R2 (TNFRSF10B Produkte)
    Synonyme
    TNFRSF10B, dr5, cd262, killer, trick2, trickb, xDR-M1, xDR-M2, ztnfr9, trailr2, trick2a, trick2b, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, Ly98, MK, tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor superfamily member 10b S homeolog, tumor necrosis factor receptor superfamily member 10b L homeolog, tumor necrosis factor receptor superfamily member 10b, TNF receptor superfamily member 10b, Tnfrsf10b, TNFRSF10B, tnfrsf10b.S, tnfrsf10b.L, tnfrsf10b
    Hintergrund
    Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues, very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
    Molekulargewicht
    40.4 kDa
    NCBI Accession
    NP_003833
    Pathways
    p53 Signalweg, Apoptose, Positive Regulation of Endopeptidase Activity
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