CLEC7A Protein (rFc Tag)

Produktnummer ABIN7535777

Produktdetails

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CLEC7A Protein ist gelabelt mit rFc Tag.

Verwendungszweck: Recombinant Human CLEC7A/Dectin-1/CD369 Protein

Sequenz: TMAIWRSNSG SNTLENGYFL SRNKENHSQP TQSSLEDSVT PTKAVKTTGV LSSPCPPNWI IYEKSCYLFS MSLNSWDGSK RQCWQLGSNL LKIDSSNELG FIVKQVSSQP DNSFWIGLSR PQTEVPWLWE DGSTFSSNLF QIRTTATQEN PSPNCVWIHV SVIYDQLCSV PSYSICEKKF SM

Spezifität: Thr66-Met247

Reinheit: > 95 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: <0.1EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Andere Bezeichnung: CLEC7A/Dectin-1/CD369 (CLEC7A Produkte)

Synonyme: CLEC7A Protein, BGR Protein, Clecsf12 Protein, beta-GR Protein, CANDF4 Protein, CLECSF12 Protein, DECTIN1 Protein, Clec7b Protein, RGD1565140 Protein, C-type lectin domain containing 7A Protein, C-type lectin domain family 7, member a Protein, CLEC7A Protein, Clec7a Protein

Hintergrund:

Description: Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

Name: CLEC7A,BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2

Gen-ID: 64581

UniProt: Q9BXN2

Pathways: Activation of Innate immune Response