GAS6 Protein (His tag)

Produktnummer ABIN7319834

Produktdetails

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses GAS6 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human GAS6 (C-6His)

Sequenz: Ala31-Ala678

Produktmerkmale: Recombinant Human Growth Arrest-specific Protein 6 is produced by our Mammalian expression system and the target gene encoding Ala31-Ala678 is expressed with a 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized  Human AXL-His (Cat#C02B) at 10μg/ml (100 μl/well) can bind Human GAS6-His* (Cat#C01W).*: Biotinylated by NHS-biotin prior to testing.The ED50 of Recombinant Human GAS6-His* (Cat#C01W) is 0.04466 ug/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, 10 % Glycerol, pH 7.4.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Andere Bezeichnung: GAS6 (GAS6 Produkte)

Synonyme: fj34a12 Protein, zgc:63860 Protein, wu:fj34a12 Protein, MGC68463 Protein, gas6 Protein, MGC83872 Protein, GAS6 Protein, Gas-6 Protein, AXLLG Protein, AXSF Protein, growth arrest specific 6 Protein, growth arrest-specific 6 Protein, growth arrest specific 6 L homeolog Protein, growth arrest specific 6 S homeolog Protein, GAS6 Protein, gas6 Protein, gas6.L Protein, gas6.S Protein, Gas6 Protein

Hintergrund:

Background: GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

Synonym: AXLLG, AXLLGAXL stimulatory factor, AXSFAXL receptor tyrosine kinase ligand, Gas6, GAS-6, growth arrest-specific 6, growth arrest-specific protein 6

Molekulargewicht: 72.7 kDa

UniProt: Q14393

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response