GAS6 Protein (AA 31-637) (His tag)

Produktnummer ABIN7274696

Recombinant GAS6-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für GAS6 Protein (AA 31-637) (His tag) (ABIN7274696)

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Produktdetails

Proteineigenschaft: AA 31-637

Aufreinigungstag / Konjugat: Dieses GAS6 Protein ist gelabelt mit His tag.

Verwendungszweck: Cynomolgus GAS6 Protein

Sequenz: Ala31-Ala637

Produktmerkmale: Recombinant Cynomolgus GAS6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala31-Ala637.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Cynomolgus Axl, His Tag immobilized on CM5 Chip can bind Cynomolgus GAS6, His Tag with an affinity constant of 1.70 nM as determined in SPR assay (Biacore T200).,Immobilized Cynomolgus GAS6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-Gas6 Antibody, hFc Tag with the EC50 of 10.0ng/ml determined by ELISA (QC Test).,Cynomolgus GAS6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Cynomolgus GAS6 is greater than 95% as determined by SEC-HPLC.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 24 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 24 months

Antigendetails

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Andere Bezeichnung: GAS6

Hintergrund: Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM).

Molekulargewicht: 68.55 kDa. Due to glycosylation, the protein migrates to 69-74 kDa based on Bis-Tris PAGE result.

UniProt: A0A2K5VGX7

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response