ACVR2B Protein (His tag,Fc Tag)
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- Target Alle ACVR2B Proteine anzeigen
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- Human Cells
- Aufreinigungstag / Konjugat
- Dieses ACVR2B Protein ist gelabelt mit His tag,Fc Tag.
- Verwendungszweck
- Recombinant Human Activin Receptor 2B/ACVR2B Protein (Fc & His Tag)(Active)
- Sequenz
- Ser19-Thr134
- Produktmerkmale
- Recombinant Human Activin Receptor Type 2B is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, 6His tag at the C-terminus.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Human/Mouse/Rat Activin A(Cat: PKSH033807) at 5μg/ml(100 μl/well) can bind Human ACVR2B-His. The ED50 of Human ACVR2B-His is 20.58 ng/ml .
- Top Product
- Discover our top product ACVR2B Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Andere Bezeichnung
- Activin Receptor 2B/ACVR2B (ACVR2B Produkte)
- Synonyme
- ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein
- Hintergrund
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Background: Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
Synonym: Activin Receptor Type-2B, Activin Receptor Type IIB, ACTR-IIB, ACVR2B,Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-3, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor
- Molekulargewicht
- 41.3 kDa
- UniProt
- Q13705
- Pathways
- Hormone Transport, Cancer Immune Checkpoints
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