ACVR2B Protein (His tag,Fc Tag)

Produktnummer ABIN7320386

Produktdetails

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ACVR2B Protein ist gelabelt mit His tag,Fc Tag.

Verwendungszweck: Recombinant Mouse Activin Receptor 2B/ACVR2B Protein (His & Fc Tag)(Active)

Sequenz: Met 1-Thr 134

Produktmerkmale: A DNA sequence encoding the extracellular domain (Met 1-Thr 134) of mouse ACVR2B (NP_031423.1) precursor was fused with the Fc region of human IgG1 at the C-terminus.

Reinheit: > 97 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. Measured by its ability to bind biotinylated Human INHBA-his in functional ELISA.2. Measured by its ability to bind biotinylated mouse INHBA-his in functional ELISA.3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 10-50 ng/mL in the presence of 10 ng/mL recombinant Activin A.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Andere Bezeichnung: Activin Receptor 2B/ACVR2B (ACVR2B Produkte)

Synonyme: ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein

Hintergrund:

Background: ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

Synonym: 4930516B21Rik,ActRIIB

Molekulargewicht: 41 kDa

NCBI Accession: NP_031423

Pathways: Hormone Transport, Cancer Immune Checkpoints