JAK1 Protein (AA 561-852) (His tag)

Produktnummer ABIN7013428

Produktdetails

Target: JAK1 (Janus Kinase 1 (JAK1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 561-852

Spezies: Human

Quelle: Insektenzellen

Aufreinigungstag / Konjugat: Dieses JAK1 Protein ist gelabelt mit His tag.

Produktmerkmale: Human JAK1 Protein, His Tag

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 mM Tris, 500 mM NaCl, 2 mM TCEP, pH 8.0

Lagerung: -80 °C

Antigendetails

Target: JAK1 (Janus Kinase 1 (JAK1))

Andere Bezeichnung: JAK1 (JAK1 Produkte)

Synonyme: JAK1A Protein, JAK1B Protein, JTK3 Protein, AA960307 Protein, C130039L05Rik Protein, wu:fb93e10 Protein, jak1 Protein, Janus kinase 1 Protein, tyrosine-protein kinase JAK1 Protein, JAK1 Protein, Jak1 Protein, jak1 Protein, LOC100286690 Protein

Hintergrund: JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

Molekulargewicht: 35.7 kDa

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response