IL-10 Protein (AA 19-178) (His tag)
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- Target Alle IL-10 (IL10) Proteine anzeigen
- IL-10 (IL10) (Interleukin 10 (IL10))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 19-178
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses IL-10 Protein ist gelabelt mit His tag.
- Verwendungszweck
- IL-10 (human) (rec.) (His)
- Spezifität
- Human IL-10 (aa 19-178) is fused at the C-terminus to a His-tag.
- Produktmerkmale
- Protein. Human IL-10 (aa 19-178) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >95 % (SDS-PAGE). Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
- Reinheit
- >95 % (SDS-PAGE)
- Endotoxin-Niveau
- <0.01EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
- Top Product
- Discover our top product IL10 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Konzentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handhabung
- Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- IL-10 (IL10) (Interleukin 10 (IL10))
- Andere Bezeichnung
- IL-10 (IL10 Produkte)
- Synonyme
- CSIF Protein, GVHDS Protein, IL-10 Protein, IL10A Protein, TGIF Protein, Il-10 Protein, IL10X Protein, interleukin 10 Protein, IL10 Protein, Il10 Protein
- Hintergrund
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Alternate Names/Synonyms: Interleukin-10, Cytokine Synthesis Inhibitory Factor, CSIF
Product Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
- Molekulargewicht
- ~18kDa (SDS-PAGE)
- NCBI Accession
- NP_000563
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
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