Interleukin 10 (IL10) (AA 19-178) (Active) Protein

Details zu Produkt Nr. ABIN2018051
Proteinname
  • CSIF
  • GVHDS
  • IL-10
  • IL10A
  • TGIF
  • Il-10
  • IL10X
  • interleukin 10
  • IL10
  • Il10
Proteineigenschaft
AA 19-178
51
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Spezies
Human
75
33
21
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Quelle
CHO Cells
104
26
18
11
3
2
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Optionen
Produktmerkmale ED50 < 0.2 ng/mL, measured in a cell proliferation assay using MC/9 cells.
Reinheit > 95 % as analyzed by SDS-PAGE and HPLC.
Endotoxin-Niveau < 0.2 EU/μg, determined by LAL method.
Proteinname
Hintergrund Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80 % sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory, however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
Synonyms: B-TCGF, CSIF, TGIF
Molekulargewicht 18-19 kDa, observed by reducing SDS-PAGE.
UniProt P22301
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstituted in ddH2O or PBS at 100 μg/mL.
Buffer Lyophilized after extensive dialysis against PBS.
Lagerung -80 °C
Informationen zur Lagerung Lyophilized recombinant Human Interleukin-10 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-10 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
Haltbarkeit 6 months
Bilder des Herstellers
SDS-PAGE (SDS) image for Interleukin 10 (IL10) (AA 19-178) (Active) protein (ABIN2018051) 5 μg of IL-10, Human was resolved with SDS-PAGE under reducing (R) and non-reducing ...
 image for Interleukin 10 (IL10) (AA 19-178) (Active) protein (ABIN2018051) Interleukin 10 (IL10) (AA 19-178) (Active) protein (Image 2)
Activity Assay (AcA) image for Interleukin 10 (IL10) (AA 19-178) (Active) protein (ABIN2018051) IL-10, Human stimulates cell proliferation of the MC/9 cells. The ED50 for this effec...
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