Ubiquitin B Protein (UBB) (His tag)

Produktnummer ABIN5505796

Produktdetails

Target: Ubiquitin B (UBB)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Ubiquitin B Protein ist gelabelt mit His tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Purified recombinant protein of Human ubiquitin B (UBB), full length, with N-terminal HIS tag, expressed in E.coli, 50 μg (full length, N-term HIS tag) protein expressed in E.coli.
• Produced with end-sequenced ORF clone

Aufreinigung: Purified

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the N-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: Ubiquitin B (UBB)

Andere Bezeichnung: ubiquitin B (UBB Produkte)

Synonyme: AL033289 Protein, Rps27a Protein, Uba52 Protein, Ubb2 Protein, Ubc Protein, UBC Protein, Ubiquitin Protein, UBB Protein, Ubi-p63E Protein, im:6892314 Protein, si:ch211-202a12.3 Protein, ubc Protein, zUBC Protein, zgc:172187 Protein, ubiquitin B Protein, ubiquitin C Protein, UBB Protein, Ubb Protein, UBC Protein, ubb Protein

Hintergrund: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 25.6 kDa

NCBI Accession: NP_061828

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, Autophagie, EGFR Downregulation, Ubiquitin Proteasome Pathway