IL1RN Protein (AA 26-177)
-
- Target Alle IL1RN Proteine anzeigen
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 26-177
-
Spezies
- Human
-
Quelle
- HEK-293T Cells
- Produktmerkmale
- ED50 < 0.1 μg /mL, measured in a neutralization assay using D10S cells in the presence of 50pg/mL Human IL-1a.
- Reinheit
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IL1RN Protein
-
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Lyophilized recombinant human IL-1 Receptor Antagonist remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human IL-1 Receptor Antagonist should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Haltbarkeit
- 6 months
-
- Target
- IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
- Andere Bezeichnung
- IL-1 Receptor Antagonist (IL1RN Produkte)
- Synonyme
- DIRA Protein, ICIL-1RA Protein, IL-1RN Protein, IL-1ra Protein, IL-1ra3 Protein, IL1F3 Protein, IL1RA Protein, IRAP Protein, MVCD4 Protein, IRAP1 Protein, IL1RN Protein, IL-1RA Protein, F630041P17Rik Protein, interleukin 1 receptor antagonist Protein, interleukin 1 receptor antagonist-like Protein, IL1RN Protein, Il1rn Protein, IL1RNL Protein
- Hintergrund
-
IL-1 Receptor Antagonist, also known as IL-1RA, ICIL-1RA, IRAP and IL-1RN, is a member of the interleukin 1 cytokine family. It is expressed by monocytes, neutrophils, macrophages, epithelial cells and fibroblasts. IL-1RA inhibits the activity of both IL-1alpha and IL-1beta, and modulates a variety of IL-1 related immune and inflammatory responses. It inhibits the activity of IL-1 by binding to the receptor IL-1R1 and preventing its association with the coreceptor IL-1RAP for signaling. Clinical studies are being conducted to investigate the use of IL-1RA in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.
Synonyms: IL-1RA, ICIL-1RA, IRAP, IL-1RN - Molekulargewicht
- 18-23 kDa, observed by reducing SDS-PAGE.
- UniProt
- P18510
- Pathways
- NF-kappaB Signalweg, Hormone Transport, Cancer Immune Checkpoints
-