CDK2AP2 Protein (His tag)

Produktnummer ABIN1098497

Produktdetails

Target: CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CDK2AP2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Aufreinigung: purified by chromatography

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Kommentare:

Synonyms: cyclin-dependent kinase 2 associated protein 2, DOC-1R, p14

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 50% glycerol, 2 mM DTT

Lagerung: 4 °C

Informationen zur Lagerung: Avoid repeated freezing and thawing cycles.

Antigendetails

Target: CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))

Andere Bezeichnung: CDK2AP2 (CDK2AP2 Produkte)

Synonyme: DOC-1R Protein, p14 Protein, zgc:92182 Protein, 5830466O21Rik Protein, D19Ertd144e Protein, Doc-1r Protein, cyclin dependent kinase 2 associated protein 2 Protein, cyclin-dependent kinase 2 associated protein 2 Protein, CDK2-associated protein 2 Protein, CDK2AP2 Protein, cdk2ap2 Protein, Cdk2ap2 Protein

Hintergrund: CDK2AP2, also known as DOC-1R and p14, belongs to the CDK2AP family. CDK2-associated protein is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. CDK2AP2 is a regulator for self-renewal of mouse embryonic stem cells (mESCs) under permissive conditions, and cell survival during differentiation of the mESCs into terminally differentiated cell types. CDK2AP2 may be involved in the regulation of self-renewal of stem cells during early embryogenesis. Recombinant human CDK2AP2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 15.5kDa (149aa), confirmed by MALDI-TOF

NCBI Accession: NP_005842

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA