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anti-Mouse (Murine) PLA2G6 Antikörper:
anti-Human PLA2G6 Antikörper:
anti-Rat (Rattus) PLA2G6 Antikörper:
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Human Polyclonal PLA2G6 Primary Antibody für ICC, IF - ABIN4345957
Paliege, Roeschel, Neymeyer, Seidel, Kahl, Daigeler, Mutig, Mrowka, Ferreri, Wilson, Himmerkus, Bleich, Bachmann: Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb. in American journal of physiology. Renal physiology 2012
Show all 3 Pubmed References
Disturbances in mitochondrial potential and changes in calcium signaling are dependent on iPLA2 activity in an animal model of infantile neuroaxonal dystrophy (zeige SPTBN4 Antikörper).
The antinociceptive effect of maprotiline was abrogated by iPLA2 antisense oligonucleotide injection to the prefrontal cortex, indicating a role of this enzyme in antinociception. In contrast, injection of iPLA2 antisense oligonucleotide to the somatosensory cortex did not reduce the antinociceptive effect of maprotiline.
The absence of iPLA2beta promotes macrophage M2 polarization.
Time lapse microscopy and integrin endocytosis assay revealed the essential role of calcium-independent phospholipase A2 (zeige LYPLA1 Antikörper) activity for the recycling of alpha 6 integrin-GFP from the endosomal recycling complex to the plasma membrane.
iPLA2-gamma (zeige PNPLA8 Antikörper) has a protective functional role in the normal glomerulus and in glomerulonephritis.
Results suggest that the degeneration of dopaminergic neurons occurs mainly in the distal region of axons in iPLA2beta-KO mice.
This study showed that the absence of iPLA2beta activity does not influence myocardial inflammation, but iPLA2beta is essential for T. cruzi clearance.
Results support the deleterious role of iPLA2beta in severe obesity associated NAFLD (zeige TSC2 Antikörper).
Genetic or molecular impairment of PLA2g6-dependent Ca(2+) signalling is a trigger for autophagic dysfunction, progressive loss of dopamine (zeige CA2 Antikörper)rgic (DA) neurons in substantia nigra pars compacta and age-dependent L-DOPA-sensitive motor dysfunction.
An inactivation of iPLA2beta exacerbated pathogenesis of experimental colitis by promoting intestinal epithelial cell apoptosis, inhibiting crypt cell regeneration, and causing damage to mucus barrier allowing an activation of innate immune response.
The catalytic domains of iPLA2beta form a tight dimer and surrounded by ankyrin (zeige ANK Antikörper) repeat domains that adopt an outwardly flared orientation, poised to interact with membrane proteins.
performed a longitudinal brain volumetry study in a couple of bicorial twins with PLA2G6-positive infantile neuronal axonal dystrophy
We found no significant influence of the PLA2G6 and PLA2G4C (zeige PLA2G4C Antikörper) polymorphisms on mean age at first hospital admission (P > 0.05) and that the investigated polymorphisms significantly influenced the clinical psychopathology only in male patients. The PLA2G4C (zeige PLA2G4C Antikörper) polymorphism accounted for approximately 12% of negative symptom severity.
Study performed direct sequencing and investigated copy number variations (CNVs) of this gene in 109 Japanese patients with parkinsonism. Results suggest that CNV in PLA2G6 is rare in parkinsonism, at least in the Japanese population, in contrast to the reports of its frequency in neurodegeneration associated with brain iron accumulation.
the association of PLA2G6 with the pathogenesis of idiopathic PD, in addition to PARK14.
A novel missense mutation in PLA2G6 gene (c.3G > T:p.M1I) in one and half-year-old boy with muscle weakness and neurodevelopmental regression (speech, motor and cognition).
PLA2G6 mutations in Indian patients with infantile neuroaxonal dystrophy (zeige SPTBN4 Antikörper) and atypical late-onset neuroaxonal dystrophy (zeige SPTBN4 Antikörper)
These results strongly suggest that PNPLA9, -6 and -4 play a key role in GPL (zeige IL31RA Antikörper) turnover and homeostasis in human cells. A hypothetical model suggesting how these enzymes could recognize the relative concentration of the different GPLs is proposed
This study identifies a novel PLA2G6 mutation that is the possible genetic cause of FCMTE in this Chinese family.
Finding suggest the broadness of the clinical spectrum of group VI phospholipases A2 (PLA2G6)-related neurodegeneration.
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date.
85 kDa calcium-independent phospholipase A2
, patatin-like phospholipase domain containing 9
, phospholipase A2, group 6 (cytosolic, calcium-independent)
, phospholipase A2, group VI (cytosolic, calcium-independent)
, 85 kDa calcium-independent phospholipase A2-like
, 85/88 kDa calcium-independent phospholipase A2
, GVI PLA2
, group VI phospholipase A2
, intracellular membrane-associated calcium-independent phospholipase A2 beta
, patatin-like phospholipase domain-containing protein 9
, calcium-independent phospholipase A2
, cytosolic, calcium-independent phospholipase A2
, neurodegeneration with brain iron accumulation 2