PLA2G6 Antikörper (AA 331-430)

Produktnummer ABIN6989060

Der Kaninchen Polyklonal anti-PLA2G6 Antikörper wird verwendet zum Nachweis von PLA2G6 in Proben von Ratte und Maus. Er wurde validiert für ICC, IHC (p), IHC (fro) und IF.

Kurzübersicht für PLA2G6 Antikörper (AA 331-430) (ABIN6989060)

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLA2G6 Antikörper ist unkonjugiert

Applikation: Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Produktdetails anti-PLA2G6 Antikörper

Bindungsspezifität: AA 331-430

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CaIPLA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500
IF()
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu PLA2G6

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Andere Bezeichnung: CaIPLA2

Hintergrund:

Synonyms: 85 kDa calcium independent phospholipase A2, 85 kDa calcium-independent phospholipase A2, CaI PLA2, CaI-PLA2, CaIPLA2, Calcium independent phospholipase A2, Cytosolic calcium independent phospholipase A2, Group VI phospholipase A2, GVI, GVI PLA2, INAD1, iPLA(2)beta, iPLA2, IPLA2 VIA, iPLA2beta, NBIA2A, NBIA2B, PA2G6_HUMAN, PARK14, Patatin like phospholipase domain containing 9, Patatin like phospholipase domain containing protein 9, Phospholipase A2 calcium independent, Phospholipase A2 calcium independent group VI A, Phospholipase A2 group VI, Phospholipase A2 group VI cytosolic calcium independent, PLA2, PLA2G6, PNPLA9, PLPL9_HUMAN

Background: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Gen-ID: 8398

UniProt: O60733

Pathways: Positive Regulation of Peptide Hormone Secretion