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Cow (Bovine) Polyclonal GLUD1 Primary Antibody für IHC, WB - ABIN2782330
Kawajiri, Okano, Kuno, Tokuhara, Hase, Inada, Tashiro, Miyazaki, Yamano: Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome: role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel. in Pediatric research 2006
Show all 3 Pubmed References
near-atomic resolution cryoelectron microscopy structures, at resolutions ranging from 3.2 A to 3.6 A for GDH complexes, is reported.
Data show that glutamate (zeige GRIN2A Antikörper) dehydrogenase activity in an enzymatic catalyzed reaction by tracing the increasing of oxidation current of NADH.
Data show that heat inactivation of the native GDH enzyme occurred with a rate constant of inactivation of 0.252 min-1 (zeige CD59 Antikörper).
the existence of two partially unfolded states of GDH at moderate acidic pHs (zeige PCBD1 Antikörper) which may be considered as molten and pre-molten globule-like states.
Characterized cDNA clones of sequences GDH1 and GDH2 (zeige GLUD2 Antikörper) that code for putative alpha- and beta-subunits of the NADH dependent enzyme. Although the gene transcripts are co-localized in roots of etiolated seedlings, the ratio of the two subunits varies among tissues.
This study showed that SIRT5 (zeige SIRT5 Antikörper) supports the anaplerotic entry of glutamine (zeige GFPT1 Antikörper) into the TCA cycle in malignant phenotypes of CRC (zeige CALR Antikörper) via activating GLUD1.
the present study shows that the GDHS445L enzyme is highly sensitive to the allosteric activator ADP, explaining the hyperactivity of this mutant. INS (zeige INS Antikörper)-1E beta-cells expressing GDHS445L responded to glutamine (zeige GFPT1 Antikörper) stimulation by increasing the mitochondrial respiration and ATP production, as well as by a rise in cytosolic calcium.
We have shown that alpha-ketoglutarate substrate inhibition kinetics of GDH, which include both random and obligatory ordered association/dissociation reactions, robustly control the ratio between glutamate (zeige GRIN1 Antikörper) and ammonium under a wide range of intracellular substrate variation. Dysregulation of this activity under pericentral nitrogen insufficiency contributes to the breaking down of ammonia homeostasis and thereby can s...
mRNA and protein levels of GluD1 were increased in iPSC-derived neurons (zeige FOXG1 Antikörper) from FOXG1(+/-) patients.
Hypoxia-induced expression of GDH relies on the up-regulation of HIF1alpha (zeige HIF1A Antikörper) but not HIF2alpha (zeige EPAS1 Antikörper). HIF1alpha (zeige HIF1A Antikörper) binds the promoter of GDH and promotes the transcription of GDH gene in lung cancer cells.
Results indicate that it is possible to use high-throughput screening methods to find activators for glutamate (zeige GRIN1 Antikörper) dehydrogenase (GDH) that might be useful as pharmaceutical agents.
Missense mutation of GLUD1 is associated with Hyperinsulinism-hyperammonemia syndrome.
GLUD1 is differentially expressed in the cellular and subcellular compartments of numerous tissues.
GLUD1 mutation is associated with congenital hyperinsulinism-hyperammonemia.
Study of the expression of the GDH1/2 in human steroidogenic organs revealed that, while GDH2 (zeige GLUD2 Antikörper) was expressed specifically in steroid-synthesizing cells, GDH1 was expressed both in the cells that produce steroids and in those that lack endocrine function.
mRNA and protein levels of GluD1 were increased in fetal brain of foxg1 (zeige FOXG1 Antikörper)(+/-) mice. mRNA and protein levels of GluD1 were decreased in adult brain of foxg1 (zeige FOXG1 Antikörper)(+/-) mice.
lack of glutamate (zeige GRIN1 Antikörper) oxidation in brain-specific (zeige CALY Antikörper) GDH (zeige UGDH Antikörper) null CnsGlud1-/- mice resulted in a central energy-deprivation state with increased ADP/ATP ratios and phospho-AMPK (zeige PRKAA1 Antikörper) in the hypothalamus.
This study demonstrated a critical requirement for GluD1 in normal spine development in the cortex and hippocampus.
The GDH (zeige UGDH Antikörper) activity in mice is highest in the liver with NAD(+) as a coenzyme and highest GDH (zeige UGDH Antikörper) activity was determined at a glutamate (zeige GRIN1 Antikörper) concentration of 10 mM.
Age-related increases of glutamate (zeige GRIN1 Antikörper) were observed only in the striatum of the glutamate dehydrogenase 1 mice
Glutamate (zeige GRIN1 Antikörper) hyperactivity caused gene expression changes in the hippocampus at all ages
GluD1 regulates the connectivity of parallel fiber-interneuron synapses and promotes differentiation of interneurons.
The GDH1 is a key metabolic enzyme with emerging roles in insulin (zeige INS Antikörper) regulation. MitoNEET (zeige CISD1 Antikörper) forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator.
GluD1 is crucial for normal functioning of synapses and absence of GluD1 leads to specific abnormalities in learning and memory.
Permissive levels of glutamate (zeige GRIN1 Antikörper) are required for the full development of glucose-stimulated insulin (zeige INS Antikörper) secretion and glutamate (zeige GRIN1 Antikörper) dehydrogenase plays an indispensable role in this process.
these data illustrate the essential role of EIN3-regulated GDH (zeige UGDH Antikörper) activity in metabolic adjustment during anoxia-reoxygenation.
the carboxyl terminus of the GDH (zeige UGDH Antikörper) subunit is involved in the stabilization of the oligomeric structure of the enzyme.
In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate (zeige GRIN2A Antikörper) dehydrogenase are targeted to the mitochondria of the companion cells.
GDH (zeige UGDH Antikörper) has a major effect on the control of metabolic composition during tomato fruit ripening, but not at other stages of development.
These results indicate that GDH (zeige UGDH Antikörper) beta-subunit (zeige POLG Antikörper) could modulate the heteromeric isoforms of GDH (zeige UGDH Antikörper) in response to the environment and physiology of the tomato fruit.
This gene encodes glutamate dehydrogenase protein\; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
, glutamate dehydrogenase 1, mitochondrial
, glutamate dehydrogenase 1
, mitochondrial glutamate dehydrogenase 1
, glutamate dehydrogenase (NAD(P)+)
, memory-related gene 2 protein
, glutamate dehydrogenase 1, mitochondrial-like
, NADH-glutamate dehydrogenase
, glutamate dehydrogenase