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Human Polyclonal Adenylate Kinase 2 Primary Antibody für IHC (p), WB - ABIN392742
Noma, Song, Yoon, Tanaka, Nakazawa: cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2. in Biochimica et biophysica acta 1998
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Human Polyclonal Adenylate Kinase 2 Primary Antibody für IHC (p), WB - ABIN392741
Lee, Kim, Lee, Kim, Lee, Park, Choe: Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues. in Journal of biochemistry 1998
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Adenylate kinase 2 deficiency limits survival and regulates various genes during larval stages of Drosophila melanogaster.
Data demonstrate that adenylate kinase 2 plays a critical role in adenine nucleotide metabolism in the mitochondrial intermembrane space and is essential for growth.
Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
Knockdown of zebrafish ak2 also leads to aberrant leukocyte development, stressing the evolutionarily conserved role of AK2.
Reticular dysgenesis -patient derived induced pluripotent stem cells can recapitulate disease phenotype which can be rescued by AK2 overexpression.
In conclusion, our data suggest that SIRPalpha signaling through SHP-2 (zeige PTPN11 Antikörper)-PI3K (zeige PIK3CA Antikörper)-Akt2 (zeige AKT2 Antikörper) strongly influences osteoblast differentiation from bone marrow stromal cells.
AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.
results suggest that AK2 is an associated activator of DUSP26 (zeige DUSP26 Antikörper) and suppresses cell proliferation by FADD (zeige FADD Antikörper) dephosphorylation, postulating AK2 as a negative regulator of tumour growth.
AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis.
These results suggest that, acting in concert with FADD (zeige FADD Antikörper) and caspase-10 (zeige CASP10 Antikörper), AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis.
The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP (zeige APRT Antikörper) kinases 2
Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified.
The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis.
In addition to AK1 (zeige AK1 Antikörper) and AK2, which we previously demonstrated are present in outer dense fibers (zeige ODF1 Antikörper) and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8 (zeige AK8 Antikörper), is present in a third flagellar compartment, the axoneme.
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.
Reduced Akt2 (zeige AKT2 Antikörper) leads to up-regulation of Rab4a (zeige RAB4A Antikörper) expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha (zeige PPARA Antikörper).
AK2 in the flagellar accessory structures provides a mechanism to buffer the adenylate energy charge for sperm motility. Ak2 protein was localized to the mitochondrial sheath in the sperm midpiece.
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates\; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
, adenylate kinase-2
, adenylate kinase 2
, AK 2
, ATP-AMP transphosphorylase 2
, ATP:AMP phosphotransferase
, adenylate kinase 2, mitochondrial
, adenylate monophosphate kinase
, adenylate kinase isoenzyme 2, mitochondrial
, adenylate kinase isozyme 2