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Human Polyclonal NR1H3 Primary Antibody für GS, ICC - ABIN4331875
DiBlasio-Smith, Arai, Quinet, Evans, Kornaga, Basso, Chen, Feingold, Halpern, Liu, Nambi, Savio, Wang, Mounts, Isler, Slager, Burczynski, Dorner, LaVallie: Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. in Journal of translational medicine 2008
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Polyclonal NR1H3 Primary Antibody für WB - ABIN540837
Zhang, Yin, Liao, Huang, Tang, Tsutsumi, Wang, Liu, Li, Hou, Cai, Xiao: NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. in Journal of lipid research 2006
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Human Polyclonal NR1H3 Primary Antibody für WB - ABIN542003
Joseph, Castrillo, Laffitte, Mangelsdorf, Tontonoz: Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. in Nature medicine 2003
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Human Polyclonal NR1H3 Primary Antibody für ELISA, ICC - ABIN4331876
Ahn, Jang, Jun, Lee, Shin: Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. in Digestive diseases and sciences 2014
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Human Monoclonal NR1H3 Primary Antibody für ELISA, WB - ABIN523441
Ishibashi, Filomenko, Rébé, Chevriaux, Varin, Derangère, Bessède, Gambert, Lagrost, Masson: Knock-down of the oxysterol receptor LXR? impairs cholesterol efflux in human primary macrophages: lack of compensation by LXR? activation. in Biochemical pharmacology 2013
Human Polyclonal NR1H3 Primary Antibody für ELISA, WB - ABIN547351
Tangirala, Bischoff, Joseph, Wagner, Walczak, Laffitte, Daige, Thomas, Heyman, Mangelsdorf, Wang, Lusis, Tontonoz, Schulman: Identification of macrophage liver X receptors as inhibitors of atherosclerosis. in Proceedings of the National Academy of Sciences of the United States of America 2002
Cow (Bovine) Polyclonal NR1H3 Primary Antibody für WB - ABIN2780709
Torra, Ismaili, Feig, Xu, Cavasotto, Pancratov, Rogatsky, Neubert, Fisher, Garabedian: Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages. in Molecular and cellular biology 2008
Mouse (Murine) Polyclonal NR1H3 Primary Antibody für IHC, WB - ABIN3023023
Qian, Ma, Wu, Yu, Lin, Ying, Wen, Gao: G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE-/- mice. in Vascular pharmacology 2017
Human Polyclonal NR1H3 Primary Antibody für ChIP-seq, ChIP - ABIN2668708
Kemmerer, Wittig, Richter, Brüne, Namgaladze: AMPK activates LXRα and ABCA1 expression in human macrophages. in The international journal of biochemistry & cell biology 2016
Human Polyclonal NR1H3 Primary Antibody für WB - ABIN3043617
Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. in Molecular medicine reports 2014
Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.
In patients with systemic lupus erythematosus carrying LXRA 1830 T > C polymorphism, LXRA expression increased in macrophages; and levels of proinflammatory cytokines decreased with LXRA expression. Expression of LXRA was decreased and that of proinflammatory cytokines was increased for LXRA -1830 TC genotype compared to that for TT genotype.
LXRalpha activation antagonizes the mesenchymal, reactive oxygen species and pro-apoptotic responses to TGFbeta and the mesenchymal transcription factor Snail mediates this crosstalk. In contrast, LXRalpha activation and TGFbeta cooperate in enforcing cytostasis in HCC, which preserves their epithelial features.
Large-scale multiple sclerosis (MS) genome-wide association studies with a total of 27,148 samples including 9772 MS cases and 17,376 controls, and multiple expression quantitative trait loci datasets. The results suggest that rs7120118 and rs2279238 variants are significantly associated with MS risk, and could significantly regulate NR1H3 expression in kinds of human tissues and cells.
ENHO, RXRA, and LXRA polymorphisms and dyslipidemia, related comorbidities and survival in hemodialysis patients have been reported.
we found that siphonaxanthin (SPX), blocked LXR-alpha activation and would be a promising candidate for antagonist of LXR-alpha .
The authors report that, in Mycobacterium tuberculosis-infected macrophages, IL-36 signaling modulates cholesterol biosynthesis and efflux via LXR.
LXR-alpha played a central role in down-regulating of ABCA1 and ABCG1 and lipid accumulation induced by homocysteine in the macrophages.
LXRalpha interacts with OGT in its N-terminal domain and ligand-binding domain (LBD) in a ligand-independent fashion.
Our data suggest that LXR could be used as a biomarker for hepatocellular carcinoma prognosis.
PBMCs from healthy persons were predisposed to the MPhi2 differentiation phenotype, which exhibits elevated cholesterol uptake and anti-inflammatory properties. LXRalpha over-expression polarizes macrophages towards the anti-inflammatory MPhi2 phenotype.
LXR gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 levels.
In conclusion, the present study demonstrated that activation of LXRalpha-ABCA1 axis with a synthetic LXR agonist TO90 exerted a potent protective effect against Abeta induced senescent and inflammatory responses in retinal pigment epithelial cells, suggesting that LXR agonists may be promising therapeutic agents for treating age-related macular degeneration.
AMPK activates LXRalpha and ABCA1 expression in human macrophages
PPARalpha and LXRalpha may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis
results indicated that LXRalpha plays a specific and important role in activation of TH by regulating D1, and that LXRalpha binds to and regulates the hDIO1 promoter, competing with TRbeta on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (LXRbeta) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
LXRs regulate the Kupffer cell/macrophage population and innate immune and inflammatory responses in mouse liver.
Authors report that the genetic ablation of both LXR isoforms (LXRalpha and beta) in mice (LXRdKO) provokes significant locomotor defects correlated with enhanced anion superoxide production, lipid oxidization and protein carbonylation in the sciatic nerves.
Type I interferon increases liver X receptor (LXR) expression following gammaherpesvirus infection. Gammaherpesvirus replication is increased in macrophages derived from mice genetically deficient in both LXRalpha and LXRbeta isoforms. LXR suppresses the expression of target genes, leading to decreased fatty acid and cholesterol synthesis, two metabolic pathways that support gammaherpesvirus replication in primary macr...
LXRalpha(-/-) mice exhibited decreased hepatic G0S2 expression. The LXRalpha-G0S2 axis plays a distinct role in regulating hepatic triglycerides during both fasting and pharmacological activation of LXR.
LXRalpha positively regulates Fsp27a and Fsp27b expression.
Mechanistic studies reveal that MeXis interacts with and guides promoter binding of the transcriptional coactivator DDX17. The identification of MeXis as a lncRNA modulator of LXR-dependent gene expression expands understanding of the mechanisms underlying cell type-selective actions of nuclear receptors in physiology and disease.
LXRalpha regulates hepatic immune function along with lipid metabolism and protects against the pathogenesis of nonalcoholic steatohepatitis.
It was concluded that quercetin inhibits oxLDLinduced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXRalpha and downregulation of PCSK9, p53, p21 and p16.
findings demonstrate that LXRalpha phosphorylation at S196 is an important determinant of atherosclerotic plaque development through selective changes in gene transcription that affect multiple pathways
FXR signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction.
the activation of LXRs protected rd1 mouse retina and rescued visual function by suppressing the immune inflammation mediated by JAK3-STAT pathway. LXRs agonist might become new therapeutic agents for RP.
The LXR agonist TO901317 had potent antioxidant, anti-inflammatory, and antiapoptotic effects against PQ-induced Acute Lung Injury
the anti-inflammatory effect of Saikosaponin a is associated with activating LXRalpha dependent cholesterol efflux pathway which result in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 to lipid rafts, thereby attenuating LPS mediated inflammatory response
The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis.
the agonists inhibited the priming of inflammasome activation. In vivo data also showed that LXRs agonist prevented NLRP3-dependent peritonitis. In conclusion, LXRs agonists are identified to potently suppress NLRP3 inflammasome and the regulation of LXRs signaling is a potential therapeutic for inflammasome-driven diseases.
LXR activation impairs adipose expansion by increasing adipocyte apoptosis, lipolysis and antagonising PPARgamma-mediated transcriptional activity, which contributes to decreased insulin sensitivity in whole body.
The present study indicates a requirement for C/EBPbeta in the insulin-mediated induction of SREBP-1c mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors.
The deletion of Srebf-2 and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR activity and SREBP-1c expression.
involved in the renal expression of lipogenic enzymes
role in transcriptional regulation of lipid synthesis in a mammary epithelial cell line
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.
Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.
Allele A of the exon5-A201C in NR1H3 promotes a reduction in backfat thicknes.NR1H3 plays role in lipid deposition.
discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
nuclear receptor subfamily 1, group H, member 3
, oxysterols receptor LXR-alpha-like
, liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha
, LXR alpha
, liver X receptor alpha
, ubiquitously-expressed nuclear receptor 1
, nuclear orphan receptor LXR-alpha
, nuclear receptor subfamily 1 group H member 3
, liver X receptor
, nuclear oxysterol receptor LxR-alpha