NR1H3 Antikörper (C-Term)

Produktnummer ABIN6263715

Produktdetails anti-NR1H3 Antikörper

Target: NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1H3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: NR1H3 Antibody detects endogenous levels of total NR1H3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NR1H3, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NR1H3

Target: NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))

Andere Bezeichnung: NR1H3 (NR1H3 Produkte)

Synonyme: NR1H3 antikoerper, LXR-a antikoerper, LXRA antikoerper, RLD-1 antikoerper, AU018371 antikoerper, LXR antikoerper, RLD1 antikoerper, Unr1 antikoerper, LXRalpha antikoerper, LXR-alpha antikoerper, im:7141239 antikoerper, wu:fd59b01 antikoerper, zgc:113339 antikoerper, zgc:158542 antikoerper, nuclear receptor subfamily 1 group H member 3 antikoerper, nuclear receptor subfamily 1, group H, member 3 antikoerper, NR1H3 antikoerper, nr1h3 antikoerper, Nr1h3 antikoerper

Hintergrund:

Description: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).

Gene: NR1H3

Molekulargewicht: 50kDa

Gen-ID: 10062

UniProt: Q13133

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding, Cellular Response to Molecule of Bacterial Origin, Hepatitis C