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anti-Human NOTCH3 Antikörper:
anti-Mouse (Murine) NOTCH3 Antikörper:
anti-Rat (Rattus) NOTCH3 Antikörper:
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Human Monoclonal NOTCH3 Primary Antibody für ELISA, WB - ABIN562028
Park, Shih, Wang: Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. in Cancer research 2008
Show all 7 Pubmed References
Human Polyclonal NOTCH3 Primary Antibody für IHC - ABIN966682
Joutel, Corpechot, Ducros, Vahedi, Chabriat, Mouton, Alamowitch, Domenga, Cécillion, Marechal, Maciazek, Vayssiere, Cruaud, Cabanis, Ruchoux, Weissenbach, Bach, Bousser, Tournier-Lasserve: Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. in Nature 1996
Show all 3 Pubmed References
Human Polyclonal NOTCH3 Primary Antibody für IHC - ABIN966685
Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: Human ligands of the Notch receptor. in The American journal of pathology 1999
Show all 3 Pubmed References
Mouse (Murine) Monoclonal NOTCH3 Primary Antibody für FACS - ABIN2475922
Droese, Pape, Stolley: [Lipic content and fatty acid pattern in human milk and cow's milk (author's transl)]. in European journal of pediatrics 1976
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Mouse (Murine) Polyclonal NOTCH3 Primary Antibody für BR, CyTOF - ABIN5012974
Blanpain, Lowry, Pasolli, Fuchs: Canonical notch signaling functions as a commitment switch in the epidermal lineage. in Genes & development 2006
Show all 2 Pubmed References
Human Polyclonal NOTCH3 Primary Antibody für IHC (fro), IHC - ABIN408754
Soylu, Acar, Ozbey, Unal, Koksal, Bassorgun, Ciftcioglu, Ustunel: Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma. in Pathology oncology research : POR 2015
Human Polyclonal NOTCH3 Primary Antibody für IHC (p), IP - ABIN250809
Dang, Fan, Chaudhry, Wang, Gaiano, Eberhart: Notch3 signaling initiates choroid plexus tumor formation. in Oncogene 2006
Human Monoclonal NOTCH3 Primary Antibody für CyTOF, FACS - ABIN4900322
Soriani, Iannitto, Ricci, Fionda, Malgarini, Morrone, Peruzzi, Ricciardi, Petrucci, Cippitelli, Santoni: Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. in Journal of immunology (Baltimore, Md. : 1950) 2014
Results found that Notch3 was more highly expressed in human urothelial cancer tissues than in non-tumorous bladder tissue samples, with Notch3 overexpression being associated with poor clinical outcome. These data suggested that Notch 3 overexpression promotes growth and chemoresistance in urothelial cancer.
Two heterozygous missense mutations in the NOTCH3 gene have been identified in two families affected with cerebral autosomal dominant arteriopathy with subcortical infarct and leucoencephalopathy
The results reveal a new connection between p38MAPK (zeige MAPK14 Antikörper), MYC (zeige MYC Antikörper) and NOTCH (zeige NOTCH1 Antikörper) signaling, demonstrate two mechanisms of NOTCH3 regulation and provide evidence for NOTCH3 involvement in prostate luminal cell differentiation.
Results identified NOTCH3 as a direct target of MIR (zeige MLXIP Antikörper)-613 which represses notch3 expression via targeting its 3'TUR. IN contrary, HOTAIR positively regulates the notch3 expression via acting as a competing endogenous RNA for miR (zeige MLXIP Antikörper)-613 binding in pancreatic cancer.
The present study identified a novel variant (chr19:15288426A>C) in the NOTCH3 gene using whole exome sequencing and confirmed it using Sanger sequencing. With multiple in silico analyses and 3D structure simulation, it is suggested that this variant has mildly damaging effects on the function of NOTCH3 gene, but can decrease protein stability.
We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k (zeige PIK3CA Antikörper)-Akt (zeige AKT1 Antikörper)
we report a rare pathogenic mutation on exon 14 of the NOTCH3 gene in a Chinese family affected by CADASIL
The SNPs rs1044009 and rs1044006 in the NOTCH3 gene were associated with the risk of cerebral infarction disease in a Chinese Han agedness population.
Oligodendrocytes expressing mutant NOTCH3(R90C) (present in CADASIL disease), exhibited aberrant NOTCH3 proteolytic processing. These cells were less viable and had a higher rate of apoptosis. Cells with NOTCH3(R90C) had higher levels of intrinsic mitochondrial apoptosis, extrinsic death receptor path-related apoptosis, and autophagy compared with cells transfected with wild-type NOTCH3.
Novel variants in NOTCH3 associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k-Akt (zeige AKT1 Antikörper)
Notch3 mutation impairs recovery of cardiac function post-myocardial ischemia.
Notch3 plays an important role in the maintenance of quiescent neural stem cells in the subependymal zone.
Lnc-LFAR1 binds directly to Smad2 (zeige SMAD2 Antikörper)/3 and promotes transcription of TGFbeta (zeige TGFB1 Antikörper), Smad2 (zeige SMAD2 Antikörper), Smad3 (zeige SMAD3 Antikörper), Notch2 (zeige NOTCH2 Antikörper) and Notch3 which, in turn, results in TGFbeta (zeige TGFB1 Antikörper) and Notch (zeige NOTCH1 Antikörper) pathway activation.
this study shows that Notch (zeige NOTCH1 Antikörper) signaling regulates basophils biological function, at least partially via the modulation of MAPK (zeige MAPK1 Antikörper)
Knock-in mice with the R169C mutation (Notch3(R170C/R170C)) exhibited similar reductions in arterial lumen, and both TgNotch3(R169C) and Notch3(R170C/R170C) mice showed increased cerebral artery expression of Notch3 target genes.
Notch3 is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 is attributable to its action on TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 (zeige SMAD3 Antikörper) signaling.
Data indicate that Notch (zeige NOTCH1 Antikörper) receptors Notch1 (zeige NOTCH1 Antikörper) and Notch3 deficiency compromises pericyte function and contributes to vascular pathologies.
In this study, authors use a smooth muscle-specific (zeige EIF3K Antikörper) deletion of Notch2 (zeige NOTCH2 Antikörper) together with a global Notch3 deletion to produce mice with combinations of mutant and wild-type Notch2 (zeige NOTCH2 Antikörper)/3 alleles in vascular smooth muscle cells
Elevated levels of TIMP3 (zeige TIMP3 Antikörper) and vitronectin (zeige VTN Antikörper), acting downstream of Notch3(ECD (zeige ECD Antikörper)) deposition, play a role in CADASIL, producing divergent influences on early CBF (zeige CEBPZ Antikörper) deficits and later white matter lesions.
The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC (zeige FUT1 Antikörper)) emergence in a non-cell-autonomous manner.
90 % of proliferating radial glia express notch1a (zeige NOTCH1A Antikörper), notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a (zeige NOTCH1A Antikörper)/1b.
Notch3 regulates oligodendrocyte precursor cells development and mbp (zeige MBP Antikörper) gene expression in larvae, and maintains vascular integrity in adults.
new role for Notch (zeige NOTCH1 Antikörper) signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population
Notch3 activity gates neural stem cell activation in the adult pallium.
Cellular correlates of Notch (zeige NOTCH1 Antikörper)-delta gene expression in the regenerating zebrafish retina.
knockdown of notch3 function in notch1a (zeige NOTCH1A Antikörper) mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Notch homolog 3
, neurogenic locus notch homolog protein 3
, Notch gene homolog 3