NOTCH3 Antikörper (C-Term)

Produktnummer ABIN6144738

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NOTCH3 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für NOTCH3 Antikörper (C-Term) (ABIN6144738)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTCH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-NOTCH3 Antikörper

Bindungsspezifität: C-Term

Sequenz: TPVSPQERPP PYLAVPGHGE EYPAAGAHSS PPKARFLRVP SEHPYLTPSP ESPEHWASPS PPSLSDWSES TPSPATATGA MATTTGALPA QPLPLSVPSS LAQAQTQLGP QPEVTPKRQV LA

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 2200 to the C-terminus of human NOTCH3 (NP_000426.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Andere Bezeichnung: NOTCH3

Hintergrund: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).,NOTCH3,CADASIL,CADASIL1,CASIL,IMF2,LMNS,notch 3,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Cell differentiation,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Neuroscience,Stem Cells,Hematopoietic Progenitors,Neural Stem Cells,Cardiovascular,Heart,Cardiogenesis,NOTCH3

Molekulargewicht: 243 kDa

Gen-ID: 4854

UniProt: Q9UM47

Pathways: Notch Signalweg