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anti-Human GNAQ Antikörper:
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Chicken Monoclonal GNAQ Primary Antibody für IF, WB - ABIN968914
Dutt, Kjoller, Giel, Hall, Toksoz: Activated Galphaq family members induce Rho GTPase activation and Rho-dependent actin filament assembly. in FEBS letters 2002
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Chicken Monoclonal GNAQ Primary Antibody für IF, WB - ABIN968915
Li, Iyengar: Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 3 Pubmed References
Human Monoclonal GNAQ Primary Antibody für ELISA, WB - ABIN516106
Sánchez-Fernández, Cabezudo, Caballero, García-Hoz, Tall, Klett, Michnick, Mayor, Ribas: Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector. in The Journal of biological chemistry 2016
Human Polyclonal GNAQ Primary Antibody für ELISA, WB - ABIN4315225
Ngai, Inngjerdingen, Berge, Taskén: Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. in BMC immunology 2009
Nine of 13 cases (69%) of anastomosing hemangiomas harbored a somatic mutation at GNAQ codon 209
It is therefore concluded that Gnaq plays a pivotal role in antioxidation in neural cells. A possible mechanism for this would be that the overexpressed Gnaq inhibits the cellular damaging effect mediated by NF-kappaB and Erk1/2 signal pathways.
Parathyroid hormone (zeige PTH Antikörper) controls bone and kidney homeostasis via GNAS (zeige GNAS Antikörper) and Gq-G11 (zeige STK19 Antikörper) heterotrimeric G proteins. (Review)
There were no significant differences in the prevalence of GNAQ and GNA11 (zeige GNA11 Antikörper) mutations between patients with or without metastatic disease
we report a previously unknown role for Gaq in maintenance of MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper)-induced acute myeloid leukemia (zeige BCL11A Antikörper) leukemia
Study demonstrated that the GNAQ p.R183Q mutation resides within endothelial cells in Sturge-Weber syndrome (SWS) brain lesions, and that the SWS brain endothelial cells can be isolated and expanded in culture and further confirm that the GNAQ p.R183Q mutation is present in brain endothelial cells.
Phospholipase C beta connects G protein signaling with RNA interference. (Review)
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (zeige SOX10 Antikörper) expression and presence of the BRAF (zeige BRAF Antikörper) V600E mutation.
Mutations in GNAQ and GNA11 (zeige GNA11 Antikörper) genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
These results indicate that the mechanism by which Galphaq and PLC (zeige HSPG2 Antikörper)-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined.
The Galphas (zeige GNAS Antikörper) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Antikörper), respectively. The beta2-AR/Galphas (zeige GNAS Antikörper) peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Antikörper)/Galphaq peptide interactions are predominantly hydrophobic.
The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.
atomic structure of GRK2 (zeige ADRBK1 Antikörper) in complex with Galphaq and Gbetagamma, in which the activated Galpha (zeige SUCLG1 Antikörper) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]
these data highlighted the critical role of Galphaq in regulating Th17 differentiation and multiple sclerosis pathogenesis
in colonic crypt cultures, the GLP-1 (zeige GCG Antikörper) secretion induced by such Gq + Gs GPR40 (zeige FFAR1 Antikörper) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (zeige TGFB1 Antikörper) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (zeige IL33 Antikörper) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the impaired working memory in forebrain-specific Perk (zeige EIF2AK3 Antikörper) knockout mice may stem from altered Gq protein-coupled intracellular Ca(2 (zeige CA2 Antikörper)+) dynamics in cortical pyramidal neurons.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (zeige HAND1 Antikörper) differentiation
Fluid shear stress acts on the Galphaq-ERK5 (zeige MAPK7 Antikörper) signaling pathway to upregulate Cyclin B1 (zeige CCNB1 Antikörper) and CDK1 (zeige CDK1 Antikörper) expression, thereby resulting in MC3T3-E1 cell proliferation.
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (zeige CRH Antikörper) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
, guanine nucleotide-binding protein G(q) subunit alpha
, guanine nucleotide-binding protein alpha-q
, G alpha q
, guanine nucleotide binding protein alpha q subunit
, guanine nucleotide binding protein, alpha q polypeptide
, guanine nucleotide regulatory protein G alpha q
, heterotrimeric guanine nucleotide-binding protein alpha q subunit
, guanine nucleotide-binding protein G(q) alpha subunit