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anti-Human GNAQ Antikörper:
anti-Rat (Rattus) GNAQ Antikörper:
anti-Mouse (Murine) GNAQ Antikörper:
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Human Monoclonal GNAQ Primary Antibody für ELISA, WB - ABIN516106
Sánchez-Fernández, Cabezudo, Caballero, García-Hoz, Tall, Klett, Michnick, Mayor, Ribas: Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector. in The Journal of biological chemistry 2016
Human Polyclonal GNAQ Primary Antibody für ELISA, WB - ABIN4315225
Ngai, Inngjerdingen, Berge, Taskén: Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. in BMC immunology 2009
common conjunctival melanocytic nevi have mutually exclusive mutations in BRAF and NRAS. The two conjunctival blue nevi harbored GNAQ mutations. This suggests the driver mutations of conjunctival nevi are similar to those of nevi of the skin. At the molecular level, conjunctival nevi appear more like cutaneous nevi than choroidal nevi
The results show that postzygotic mosaicism for GNAQ mutations causes an overlapping phenotypic spectrum of vascular and melanocytic birthmarks.
Results demonstrate that the somatic GNAQ mutation in Sturge-Weber syndrome is not confined to the venous vascular malformation but can directly (although less severely) affect underlying brain parenchyma, not directly affected by leptomeningeal angiomatosis, and possibly contribute to Sturge-Weber syndrome brain pathology.
GNAQ/GNA11Q209 mutations characterized a distinct, albeit uncommon subtype of non-uveal melanoma (0.5-1%). These mutations were essentially melanoma-specific, occurred in all subtypes of this disease (including cutaneous, mucosal, uveal, and unknown primary), and were mutually exclusive with other common melanoma mutations.
We conclude that the crosstalk between angiotensin AT1 receptor (zeige AGTRAP Antikörper) and insulin receptor (zeige INSR Antikörper) signaling shows a high degree of specificity, and involves Galphaq protein, and activation of distinct kinases. Thus, the BRET (zeige DNER Antikörper)(2) technique can be used as a platform for studying molecular mechanisms of crosstalk between insulin receptor (zeige INSR Antikörper) and 7TM receptors.
Nine of 13 cases (69%) of anastomosing hemangiomas harbored a somatic mutation at GNAQ codon 209
It is therefore concluded that Gnaq plays a pivotal role in antioxidation in neural cells. A possible mechanism for this would be that the overexpressed Gnaq inhibits the cellular damaging effect mediated by NF-kappaB and Erk1/2 signal pathways.
Parathyroid hormone (zeige PTH Antikörper) controls bone and kidney homeostasis via GNAS (zeige GNAS Antikörper) and Gq-G11 (zeige STK19 Antikörper) heterotrimeric G proteins. (Review)
There were no significant differences in the prevalence of GNAQ and GNA11 (zeige GNA11 Antikörper) mutations between patients with or without metastatic disease
we report a previously unknown role for Gaq in maintenance of MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper)-induced acute myeloid leukemia (zeige BCL11A Antikörper) leukemia
The Galphas (zeige GNAS Antikörper) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Antikörper), respectively. The beta2-AR/Galphas (zeige GNAS Antikörper) peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Antikörper)/Galphaq peptide interactions are predominantly hydrophobic.
The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.
atomic structure of GRK2 (zeige ADRBK1 Antikörper) in complex with Galphaq and Gbetagamma, in which the activated Galpha (zeige SUCLG1 Antikörper) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]
these data highlighted the critical role of Galphaq in regulating Th17 differentiation and multiple sclerosis pathogenesis
in colonic crypt cultures, the GLP-1 (zeige GCG Antikörper) secretion induced by such Gq + Gs GPR40 (zeige FFAR1 Antikörper) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (zeige TGFB1 Antikörper) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (zeige IL33 Antikörper) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the impaired working memory in forebrain-specific Perk (zeige EIF2AK3 Antikörper) knockout mice may stem from altered Gq protein-coupled intracellular Ca(2 (zeige CA2 Antikörper)+) dynamics in cortical pyramidal neurons.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (zeige HAND1 Antikörper) differentiation
Fluid shear stress acts on the Galphaq-ERK5 (zeige MAPK7 Antikörper) signaling pathway to upregulate Cyclin B1 (zeige CCNB1 Antikörper) and CDK1 (zeige CDK1 Antikörper) expression, thereby resulting in MC3T3-E1 cell proliferation.
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (zeige CRH Antikörper) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
, guanine nucleotide-binding protein G(q) subunit alpha
, guanine nucleotide-binding protein alpha-q
, G alpha q
, guanine nucleotide binding protein alpha q subunit
, guanine nucleotide binding protein, alpha q polypeptide
, guanine nucleotide regulatory protein G alpha q
, heterotrimeric guanine nucleotide-binding protein alpha q subunit
, guanine nucleotide-binding protein G(q) alpha subunit