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Human CD19 Protein expressed in HEK-293 Cells - ABIN2180713
De Oliveira, Wang, Ryan, Morrison, Kohn, Hollis: A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors. in Journal of translational medicine 2013
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The preclinical activity, safety and PK profile support clinical investigation of MGD011 (MGD011 is a CD19 x CD3 (zeige CD3 Proteine) DART bispecific protein )as a therapeutic candidate for the treatment of B-cell malignancies
this study shows that CD19 isoforms enable resistance to adoptive cellular immunotherapy
Anti-CD19-chimeric antigen receptors T cells synergistically exerted collaborative cytotoxicity against primary double-hit lymphoma cells with anti-CD38-chimeric antigen receptors T cells.
Two infants with relapsed, refractory B-cell acute lymphoblastic leukemia went into complete remission after being treated with CD19-targeting CAR T cells derived from an unmatched donor
These data provide proof-of-principle for the view that newly generated Ab-secreting cells can acquire a mature plasma cell phenotype that is accompanied by loss of CD19 expression at an early stage of differentiation and that aging is not an obligate requirement for a CD19(neg) state to be established.
Results indicate the strong efficacy of FLAG-tagged CD19 CAR-T cells in solid and hematological cancer models.
The histological observations suggested that the patients represent diverse cases of NHL like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL. The findings indicate that patients with NHL may also be analyzed for status of PAX5, CD19 and ZAP70, and their transcriptional and post-translational variants for the differential diagnosis of NHL and therapy.
The frequencies of CD19+CD24hiCD38hi B-regulatory lymphocyte were significantly increased in children with beta-thalassemia.
a CD45 (zeige PTPRC Proteine)+/CD19 - cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma.
CD19 is required for TLR9 (zeige TLR9 Proteine)-induced B-cell activation (zeige BLNK Proteine). Hence CD19/PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)/BTK (zeige BTK Proteine) is an essential axis integrating BCRs and TLR9 (zeige TLR9 Proteine) signaling in human B cells.
This study demonstrates that antiviral protective antibody-secreting cells (ASC (zeige STS Proteine)) in the central nervous system are dependent on CD19 activation and peripheral Germinal Center formation, while accumulation of early-recruited IgD(+) B cells is CD19 independent.
this study shows that mitochondrial reactive oxygen species suppress humoral immune responses through reduction of CD19 expression and resultant B cell receptor signaling in B cells
autoimmunity induced by excessive BAFF (zeige TNFSF13B Proteine) production requires B1b B cells and CD19 signaling.
WIPF1 (zeige WIPF1 Proteine) deficiency impaired CD19 co-receptor activation and subsequent PI3 kinase (zeige PIK3CA Proteine) signaling, by distorting the actin and tetraspanin networks that lead to altered CD19 cell surface dynamics.
Syk (zeige SYK Proteine)-deficient B cells require BAFF receptor (zeige TNFRSF13C Proteine) and CD19/PI3K signaling for their long-term survival.
The selection of mature B cells is critically dependent on the expression level of the co-receptor CD19.
This inhibitory function of FcgammaRIIB in impairing the spatial-temporal colocalization of BCR (zeige BCR Proteine) and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus
These results show that the ability of CD19-CAR T-cells to home in on tumor lesions is pivotal for their anti-tumor effects in our xenograft models, and therefore may enhance the efficacy of adoptive T-cell therapy for refractory B-cell lymphoma.
Data show that effective B cell receptor (BCR (zeige BCR Proteine)) signaling requires collaboration with the coreceptor CD19 organized by the CD81 (zeige CD81 Proteine)-tetraspanin network.
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
DNA sequence analysis of the coding sequence of CD19, the CR2 co-signaling molecule.
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
B-lymphocyte antigen CD19
, B-lymphocyte surface antigen B4
, T-cell surface antigen Leu-12
, differentiation antigen CD19
, CD19 antigen
, B cell surface marker CD19
, CD19 molecule
, b-lymphocyte antigen CD19-like
, Differentiation antigen CD19