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Human CD19 Protein expressed in HEK-293 Cells - ABIN2180713
De Oliveira, Wang, Ryan, Morrison, Kohn, Hollis: A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors. in Journal of translational medicine 2013
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CD4 (zeige CD4 Proteine)(+) and CD19(+) peripheral lymphocytes of early stage AD patients exhibit mitochondrial depletion, as seen both at the level of DNA and protein
The impairment of Bregs and CD19+/BTLA (zeige BTLA Proteine)+ cells could play an important pathogenic role in multiple sclerosis (MS).
Inhibition of Akt (zeige AKT1 Proteine) signaling during ex vivo priming and expansion gives rise to CD19CAR T cell populations that display comparatively higher antitumor activity
CD19-specific triplebody SPM (zeige NPC1 Proteine)-1 mediated potent lysis of cancer-derived B cell lines and primary cells from patients with various B-lymphoid malignancies.
The increase in CD19+CD24 (zeige CD24 Proteine)+CD27 (zeige CD27 Proteine)+ Bregs was closely associated with fasting insulin (zeige INS Proteine) secretion.
The preclinical activity, safety and PK profile support clinical investigation of MGD011 (MGD011 is a CD19 x CD3 (zeige CD3 Proteine) DART bispecific protein )as a therapeutic candidate for the treatment of B-cell malignancies
this study shows that CD19 isoforms enable resistance to adoptive cellular immunotherapy
Anti-CD19-chimeric antigen receptors T cells synergistically exerted collaborative cytotoxicity against primary double-hit lymphoma cells with anti-CD38-chimeric antigen receptors T cells.
Two infants with relapsed, refractory B-cell acute lymphoblastic leukemia went into complete remission after being treated with CD19-targeting CAR T cells derived from an unmatched donor
These data provide proof-of-principle for the view that newly generated Ab-secreting cells can acquire a mature plasma cell phenotype that is accompanied by loss of CD19 expression at an early stage of differentiation and that aging is not an obligate requirement for a CD19(neg) state to be established.
This study demonstrates that antiviral protective antibody-secreting cells (ASC (zeige STS Proteine)) in the central nervous system are dependent on CD19 activation and peripheral Germinal Center formation, while accumulation of early-recruited IgD(+) B cells is CD19 independent.
this study shows that mitochondrial reactive oxygen species suppress humoral immune responses through reduction of CD19 expression and resultant B cell receptor signaling in B cells
autoimmunity induced by excessive BAFF (zeige TNFSF13B Proteine) production requires B1b B cells and CD19 signaling.
WIPF1 (zeige WIPF1 Proteine) deficiency impaired CD19 co-receptor activation and subsequent PI3 kinase (zeige PIK3CA Proteine) signaling, by distorting the actin and tetraspanin networks that lead to altered CD19 cell surface dynamics.
Syk (zeige SYK Proteine)-deficient B cells require BAFF receptor (zeige TNFRSF13C Proteine) and CD19/PI3K signaling for their long-term survival.
The selection of mature B cells is critically dependent on the expression level of the co-receptor CD19.
This inhibitory function of FcgammaRIIB in impairing the spatial-temporal colocalization of BCR (zeige BCR Proteine) and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus
These results show that the ability of CD19-CAR T-cells to home in on tumor lesions is pivotal for their anti-tumor effects in our xenograft models, and therefore may enhance the efficacy of adoptive T-cell therapy for refractory B-cell lymphoma.
Data show that effective B cell receptor (BCR (zeige BCR Proteine)) signaling requires collaboration with the coreceptor CD19 organized by the CD81 (zeige CD81 Proteine)-tetraspanin network.
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
DNA sequence analysis of the coding sequence of CD19, the CR2 co-signaling molecule.
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
B-lymphocyte antigen CD19
, B-lymphocyte surface antigen B4
, T-cell surface antigen Leu-12
, differentiation antigen CD19
, CD19 antigen
, B cell surface marker CD19
, CD19 molecule
, b-lymphocyte antigen CD19-like
, Differentiation antigen CD19