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CD19 Molecule (CD19) (AA 20-291) (Active) protein (Fc Tag) Protein

CD19 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed (2 Referenzen)
Produktnummer ABIN2180715
$451.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle CD19 Proteine anzeigen
    CD19
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 20-291
    Spezies
    • 24
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Quelle
    • 19
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD19 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 20-291
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.3 kDa. The protein migrates as 56-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 0.1 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Hsu, Boudova, Mvula, Divala, Mungwira, Harman, Laufer, Pauza, Cairo: "Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 5, pp. 1884-92, (2017) (PubMed).

    De Oliveira, Wang, Ryan, Morrison, Kohn, Hollis: "A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors." in: Journal of translational medicine, Vol. 11, pp. 23, (2013) (PubMed).

  • Target
    CD19
    Andere Bezeichnung
    CD19 (CD19 Produkte)
    Synonyme
    B4, CVID3, AW495831, CD19, CD19 molecule, CD19 antigen, CD19, Cd19
    Hintergrund
    B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I  membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.
    Molekulargewicht
    56.3 kDa
    NCBI Accession
    NP_001761
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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