anti-Ratte (Rattus) Adrenergic, Beta, Receptor Kinase 1 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended Adrenergic, Beta, Receptor Kinase 1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antikörper
  • Adrbk-1
  • Bark-1
  • GRK2
  • betaARK1
  • BARK1
  • BETA-ARK1
  • GRK-2
  • Grk2
  • beta-adrenergic receptor kinase 1
  • G protein-coupled receptor kinase 2
  • Tsp_00497
  • grk2
  • Grk2
  • GRK2
Reaktivität
Human, Maus, Ratte (Rattus)
135
71
70
17
13
12
9
5
4
3
3
1
1
1
1
Wirt
Kaninchen
92
26
16
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
4
4
4
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
117
73
53
24
18
11
4
3
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN499029
$ 390.50
Zzgl. Versandkosten $45.00
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General

Antigen Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(135), (71), (70), (17), (13), (12), (9), (5), (4), (3), (3), (1), (1), (1), (1)
Wirt Kaninchen
(92), (26), (16), (2)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(4), (4), (4), (1), (1), (1)
Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(117), (73), (53), (24), (18), (11), (4), (3), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Spezifität This antibody detects endogenous levels of GRK 2 protein. (region surrounding Val678)
Kreuzreaktivität (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Reinigung Affinity chromatography
Reinheit > 95 % by SDS-PAGE

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung beta-ARK-1 / ADRBK1 (ADRBK1 Antibody Abstract)
Hintergrund Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1, two forms of β-adrenergic receptor kinase, GRK 2 (βARK, βARK1) and GRK 3 (βARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.Synonyms: BARK, BARK1, Beta-adrenergic receptor kinase 1, G-protein coupled receptor kinase 2, GRK2
Molekulargewicht approx. 80 kDa
Gen-ID 156
NCBI Accession NP_001610
UniProt P25098
Pathways EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Konzentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody (ABIN499029) Immunohistochemistry (IHC) analyzes of GRK 2 antibody in paraffin-embedded hum...
Western Blotting (WB) image for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody (ABIN499029) Western blot (WB) analysis of GRK 2 antibody in extracts from Jurkat cells.