GRK2 Produkte
(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
Kategorien
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008].
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Ausgewählte GRK2 Kategorien
GRK2 Antikörper
High quality antibodies with extensive validation data.
GRK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
GRK2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene GRK2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), IF, ICC, FACS, IP
Validierungen
- (6)
Kat. Nr.
ABIN2855125
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (6)
Kat. Nr.
ABIN3022346
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Monkey, Mouse, Rat
Applikation
WB, ELISA, IHC, ICC
Validierungen
- (2)
- (4)
Kat. Nr.
ABIN969178
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene GRK2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6964661
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6964660
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6964659
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene GRK2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5570618
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1344492
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3128058
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren GRK2 Produkten
: "Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study." in: Scientific reports, Vol. 8, Issue 1, pp. 12731, (2018) (PubMed).: "GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." in: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, (2009) (PubMed).
: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, (2009) (PubMed).
: "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2973-83, (2008) (PubMed).
: "Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure." in: European heart journal, Vol. 26, Issue 17, pp. 1752-8, (2005) (PubMed).
: "The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8052-7, (2003) (PubMed).
: "Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30219-26, (2003) (PubMed).
: "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated ..." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18658-63, (2003) (PubMed).
: "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase." in: World journal of gastroenterology : WJG, Vol. 9, Issue 4, pp. 800-3, (2003) (PubMed).
: "Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells." in: Anesthesiology, Vol. 98, Issue 2, pp. 343-8, (2003) (PubMed).
Synonyme und alternative Namen zu GRK2
beta-adrenergic receptor kinase 1 (Tsp_00497), G protein-coupled receptor kinase 2 (grk2), G protein-coupled receptor kinase 2 (Grk2), G protein-coupled receptor kinase 2 (GRK2), Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, GRK2, Grk2Bezeichner auf Proteinebene für GRK2
- beta-adrenergic receptor kinase 1
- adrenergic, beta, receptor kinase 1
- G-protein-coupled receptor kinase 2
- beta ARK
- beta ARK1
- beta-AR kinase-1
- beta-ARK-1
- beta-adrenergic receptor kinase-1
- G-protein coupled receptor kinase 2
- adrenergic receptor kinase, beta 1
- beta-adrenergic receptor kinase 1 beta ARK1
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