GRK2 Antikörper (N-Term)

Produktnummer ABIN7184410

Der Kaninchen Polyklonal anti-GRK2 Antikörper (ABIN7184410) detektiert spezifisch GRK2 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GRK2 Antikörper (N-Term) (ABIN7184410)

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GRK2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: ADRBK1 (Ab-86) Antibody

Kreuzreaktivität: Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human ADRBK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GRK2

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Andere Bezeichnung: ADRBK1

Hintergrund:

Background: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Benovic J.L., FEBS Lett. 283:122-126(1991).
Chuang T.T., J. Biol. Chem. 267:6886-6892(1992).
Penn R.B., J. Biol. Chem. 269:14924-14930(1994).

Aliases: ADRBK1 antibody, Adrenergic beta receptor kinase 1 antibody, ARBK1_HUMAN antibody, BARK antibody, BARK1 antibody, Beta adrenergic receptor kinase 1 antibody, Beta ARK 1 antibody, Beta ARK1 antibody, Beta-adrenergic receptor kinase 1 antibody, Beta-ARK-1 antibody, FLJ16718 antibody, G protein coupled receptor kinase 2 antibody, G-protein coupled receptor kinase 2 antibody, GRK2 antibody

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling