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anti-Human RAD51 Antikörper:
anti-Rat (Rattus) RAD51 Antikörper:
anti-Mouse (Murine) RAD51 Antikörper:
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Caenorhabditis elegans (C. elegans) Monoclonal RAD51 Primary Antibody für ChIP, ICC - ABIN151080
Chen, Chen, Chen, Xiao, Sharp, Lee: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. in Proceedings of the National Academy of Sciences of the United States of America 1998
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Human Polyclonal RAD51 Primary Antibody für - ABIN966937
Liang, Caporaso, McMaster, Ng, Landgren, Yeager, Chanock, Goldin: Common genetic variants in candidate genes and risk of familial lymphoid malignancies. in British journal of haematology 2009
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Human Monoclonal RAD51 Primary Antibody für WB - ABIN1944894
Shinohara, Ogawa, Matsuda, Ushio, Ikeo, Ogawa: Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. in Nature genetics 1993
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Human Polyclonal RAD51 Primary Antibody für IHC - ABIN966939
Rebbeck, Mitra, Domchek, Wan, Chuai, Friebel, Panossian, Spurdle, Chenevix-Trench, , Singer, Pfeiler, Neuhausen, Lynch, Garber, Weitzel, Isaacs, Couch, Narod, Rubinstein, Tomlinson, Ganz, Olopade, Tung, Blum, Greenberg, Nathanson, Daly: Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. in Cancer research 2009
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Human Polyclonal RAD51 Primary Antibody für IF, IP - ABIN2452096
Vaz, Hanenberg, Schuster, Barker, Wiek, Erven, Neveling, Endt, Kesterton, Autore, Fraternali, Freund, Hartmann, Grimwade, Roberts, Schaal, Mohammed, Rahman, Schindler, Mathew: Mutation of the RAD51C gene in a Fanconi anemia-like disorder. in Nature genetics 2010
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Human Monoclonal RAD51 Primary Antibody für IHC, WB - ABIN151942
Gultice, Kulkarni-Datar, Brown: Hypoxia-inducible factor 1alpha (HIF1A) mediates distinct steps of rat trophoblast differentiation in gradient oxygen. in Biology of reproduction 2008
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Human Polyclonal RAD51 Primary Antibody für ICC, IF - ABIN4349123
Gabriel, Roedl, Gordon, Djabali: Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. in Aging cell 2015
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Human Polyclonal RAD51 Primary Antibody für IHC (p), WB - ABIN519604
Jeyasekharan, Liu, Hattori, Pisupati, Jonsdottir, Rajendra, Lee, Sundaramoorthy, Schlachter, Kaminski, Ofir-Rosenfeld, Sato, Savill, Ayoub, Venkitaraman: A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. in Nature structural & molecular biology 2013
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Human Polyclonal RAD51 Primary Antibody für IF, IP - ABIN2668603
Bennett, Knight: Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. in Journal of cellular biochemistry 2005
Yeast (Saccharomyces cerevisiae) Polyclonal RAD51 Primary Antibody für ChIPSeq, IF - ABIN2452090
Ribeyre, Shore: Anticheckpoint pathways at telomeres in yeast. in Nature structural & molecular biology 2012
Data show that short ssDNA traverses the nuclear membrane, but is drawn into the nucleus by binding to the DNA replication and repair factors replication protein A (RPA (zeige RPA1 Antikörper)) and Rad51 recombinase (zeige RAG1 Antikörper) (Rad51).
region in the N terminus of BRCA2 (zeige BRCA2 Antikörper) exhibits DNA binding activity and promotes RAD51-mediated homologous recombination
We have identified and characterised a novel DNA damage response mechanism in melanoma. Instead of increasing levels of RAD51 on encountering cisplatin-induced interstrand crosslinks during replication, melanoma cells shut down RAD51 synthesis and instead boost levels of translesion synthesis DNA polymerase zeta to allow replication to proceed
Twenty-one different deleterious variants were identified in the RAD51 paralogs in 30 patients with ovarian and/or beast cancer.
he results of the study indicate that Akt1 (zeige AKT1 Antikörper) seems to be a regulatory component in the homologous recombination (HR) repair of DNA double-strand break in a Rad51-dependent manner.
RAD51 135G/C polymorphism was a risk factor for the three common gynecological tumors, especially for endometrial cancer among hospital-based populations.
Fanconi anemia (zeige PALB2 Antikörper)-associated RAD51 mutants are defective at stalled fork protection. Mutant RAD51 nucleoprotein filaments are unstable due to aberrant ATP binding and hydrolysis.
PTEN promotes DNA repair through Rad51-dependnent homologous recombination.
Inactivation of homologous recombination factors BRCA1, BRCA2 (zeige BRCA2 Antikörper), or RAD51 hypersensitizes cells to acetaldehyde treatment, in spite of the Fanconi anemia (zeige PALB2 Antikörper) pathway being functional.
Cells with mutated PTEN showed over-activation of the PI3K (zeige PIK3CA Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway. These cells were more sensitive to PARP (zeige COL11A2 Antikörper) inhibition compared to PTEN wild-type cells. In addition, PI3K (zeige PIK3CA Antikörper) inhibitor treatment reduced RAD51 foci formation in PTEN mutated cells, and sensitized these cells to PARP (zeige COL11A2 Antikörper) inhibitor.
Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes.
RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
Describe and demonstrate a model showing loss of RAD51 leads to Fanconi anemia (zeige PALB2 Antikörper)-like symptoms in zebrafish.
Although the presence of RAD51 protein provides essential support for the action of DMC1 (zeige DMC1 Antikörper), these results show no significant effect of the absence of RAD51 strand-exchange activity on meiotic crossing-over rates or patterns in different chromosomal regions or across the whole genome of Arabidopsis, strongly supporting the argument that DMC1 (zeige DMC1 Antikörper) catalyses repair of all meiotic DNA breaks, not only non-sister cross-overs.
The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
RAD51 forms a protein complex with AtRAD51C (zeige RAD51C Antikörper)-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.
Our data demonstrate that RAD51 plays a supporting role for DMC1 (zeige DMC1 Antikörper) in meiotic recombination in the flowering plant, Arabidopsis.
The present study demonstrates for the first time the involvement of a host RAD51 protein in mungbean yellow mosaic India virus replication.
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1 (zeige DMC1 Antikörper), while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51
AtRAD51 is required to ensure the fidelity of homologous recombination during interchromosomal exchanges. It may also be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.
Study provides the molecular evidence showing that the BRCA2 (zeige BRCA2 Antikörper)-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.
RAD51 plays a critical role in maintaining chromosome integrity and mitochondrial activity during porcine oocyte maturation.
The complete cDNA sequences of the pig RAD51, RAD52 (zeige RAD52 Antikörper), and RAD54 (zeige RAD54L Antikörper) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
RT-PCR and immunobloting data show that inhibitory effect of sodium butyrate takes place at the level of Rad51 and XRCC5 (zeige XRCC5 Antikörper) gene transcription and the content of Rad51 and Ku80 (zeige XRCC5 Antikörper) proteins.
Data show that the expression of miR (zeige MLXIP Antikörper)-193b-3p and Rad51 was altered in in response to low-dose irradiation (LDIR) exposure.
The anti-recombinase (zeige RAG1 Antikörper) activity of BLM (zeige BLM Antikörper) is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination.
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5 (zeige SWI5 Antikörper)-SFR1 (zeige SFR1 Antikörper) complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 (zeige TP53BP1 Antikörper) were recruited to these sites. H2AX (zeige H2AFX Antikörper) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Antikörper) foci formation and DSB repair, whereas H2AX (zeige H2AFX Antikörper) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Antikörper) foci were small and DSBs were not efficiently repaired
HOP2 (zeige PSMC3IP Antikörper)-MND1 (zeige MND1 Antikörper) enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
Rad51 repaired DNA damage.
BRCA2 (zeige BRCA2 Antikörper)-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions.
increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2 (zeige BRCA2 Antikörper)-mediated Rad51 polymerization
Results suggest that cellular levels of Brca2 (zeige BRCA2 Antikörper) and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (zeige TP53 Antikörper), which permits cell growth
Brca2 (zeige BRCA2 Antikörper) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 (zeige SMARCAL1 Antikörper) and Mre11 (zeige MRE11A Antikörper) predisposes to genome instability.
Data show that MRE11 (zeige MRE11A Antikörper)- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 (zeige CDC45 Antikörper) complex still engaged with the DNA could be sufficient to restore a functional CDC45 (zeige CDC45 Antikörper)-MCM-GINS (CMG (zeige CASK Antikörper)) helicase (zeige DNA2 Antikörper) complex.
By promoting CtIP (zeige RBBP8 Antikörper)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (zeige CDK1 Antikörper) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Rad51 has a role at the replication fork protecting DNA from Mre11 (zeige MRE11A Antikörper)-dependent degradation.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
BRCA1/BRCA2-containing complex, subunit 5
, DNA repair protein RAD51 homolog 1
, RAD51 homolog A
, RecA, E. coli, homolog of
, RecA-like protein
, recombination protein A
, RAD51 homolog (RecA homolog, E. coli)
, homolog to S.cerevisiae
, RAD51 homolog
, DNA repair protein RAD51
, DNA repair protein RAD51 homolog A
, RAD51 homolog (RecA homolog)
, DNA repair protein RAD51-like 1