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anti-Human RAD51 Antikörper:
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Caenorhabditis elegans (C. elegans) Monoclonal RAD51 Primary Antibody für ChIP, ICC - ABIN151080
Chen, Chen, Chen, Xiao, Sharp, Lee: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. in Proceedings of the National Academy of Sciences of the United States of America 1998
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Human Monoclonal RAD51 Primary Antibody für WB - ABIN1944894
Shinohara, Ogawa, Matsuda, Ushio, Ikeo, Ogawa: Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. in Nature genetics 1993
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Human Polyclonal RAD51 Primary Antibody für IHC - ABIN966939
Liang, Caporaso, McMaster, Ng, Landgren, Yeager, Chanock, Goldin: Common genetic variants in candidate genes and risk of familial lymphoid malignancies. in British journal of haematology 2009
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Human Polyclonal RAD51 Primary Antibody für - ABIN966937
Rebbeck, Mitra, Domchek, Wan, Chuai, Friebel, Panossian, Spurdle, Chenevix-Trench, , Singer, Pfeiler, Neuhausen, Lynch, Garber, Weitzel, Isaacs, Couch, Narod, Rubinstein, Tomlinson, Ganz, Olopade, Tung, Blum, Greenberg, Nathanson, Daly: Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. in Cancer research 2009
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Human Polyclonal RAD51 Primary Antibody für IF, IP - ABIN2452096
Vaz, Hanenberg, Schuster, Barker, Wiek, Erven, Neveling, Endt, Kesterton, Autore, Fraternali, Freund, Hartmann, Grimwade, Roberts, Schaal, Mohammed, Rahman, Schindler, Mathew: Mutation of the RAD51C gene in a Fanconi anemia-like disorder. in Nature genetics 2010
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Human Polyclonal RAD51 Primary Antibody für ICC, IF - ABIN4349123
Gabriel, Roedl, Gordon, Djabali: Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. in Aging cell 2015
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Human Monoclonal RAD51 Primary Antibody für IHC, WB - ABIN151942
Gultice, Kulkarni-Datar, Brown: Hypoxia-inducible factor 1alpha (HIF1A) mediates distinct steps of rat trophoblast differentiation in gradient oxygen. in Biology of reproduction 2008
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Human Polyclonal RAD51 Primary Antibody für IHC (p), WB - ABIN519604
Jeyasekharan, Liu, Hattori, Pisupati, Jonsdottir, Rajendra, Lee, Sundaramoorthy, Schlachter, Kaminski, Ofir-Rosenfeld, Sato, Savill, Ayoub, Venkitaraman: A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. in Nature structural & molecular biology 2013
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Yeast (Saccharomyces cerevisiae) Polyclonal RAD51 Primary Antibody für ChIPSeq, IF - ABIN2452090
Ribeyre, Shore: Anticheckpoint pathways at telomeres in yeast. in Nature structural & molecular biology 2012
Human Polyclonal RAD51 Primary Antibody für ChIPSeq, IP - ABIN2452091
Tashiro, Walter, Shinohara, Kamada, Cremer: Rad51 accumulation at sites of DNA damage and in postreplicative chromatin. in The Journal of cell biology 2000
Evidence has been provided that the majority of the Cas9-induced single nicks at the target DNA strand rely on RAD51 and BRCA2 for efficient and scar-less DNA repair.
RAD51 135G>C polymorphism is not associated with colorectal cancer.
Data show that short ssDNA traverses the nuclear membrane, but is drawn into the nucleus by binding to the DNA replication and repair factors replication protein A (RPA) and Rad51 recombinase (Rad51).
region in the N terminus of BRCA2 exhibits DNA binding activity and promotes RAD51-mediated homologous recombination
We have identified and characterised a novel DNA damage response mechanism in melanoma. Instead of increasing levels of RAD51 on encountering cisplatin-induced interstrand crosslinks during replication, melanoma cells shut down RAD51 synthesis and instead boost levels of translesion synthesis DNA polymerase zeta to allow replication to proceed
Twenty-one different deleterious variants were identified in the RAD51 paralogs in 30 patients with ovarian and/or beast cancer.
he results of the study indicate that Akt1 seems to be a regulatory component in the homologous recombination (HR) repair of DNA double-strand break in a Rad51-dependent manner.
RAD51 135G/C polymorphism was a risk factor for the three common gynecological tumors, especially for endometrial cancer among hospital-based populations.
Fanconi anemia-associated RAD51 mutants are defective at stalled fork protection. Mutant RAD51 nucleoprotein filaments are unstable due to aberrant ATP binding and hydrolysis.
PTEN promotes DNA repair through Rad51-dependnent homologous recombination.
Inactivation of homologous recombination factors BRCA1, BRCA2, or RAD51 hypersensitizes cells to acetaldehyde treatment, in spite of the Fanconi anemia pathway being functional.
Cells with mutated PTEN showed over-activation of the PI3K/mTOR pathway. These cells were more sensitive to PARP inhibition compared to PTEN wild-type cells. In addition, PI3K inhibitor treatment reduced RAD51 foci formation in PTEN mutated cells, and sensitized these cells to PARP inhibitor.
DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1, RAD51, XRCC1 and XRCC3 genes in BC patients and the control group. Two variants in the 5'-UTR of the XRCC3 and RAD51 genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 gene.
our data demonstrated for the first time that inhibition of RAD51 suppressed the cervical cancer cell proliferation and the growth of cervical cancer xenografts by attenuating cell cycle transition, which could be a functional link between RAD51 and cyclin D1 and p21.
Low RAD51 gene expression is associated with breast cancer.
(-)-Guaiol is involved in cell autophagy to regulate the expression of RAD51, leading to double-strand breaks triggered cell apoptosis
Report a requirement for PARP2 in stabilizing replication forks that encounter base excision repair (BER) intermediates through Fbh1-dependent regulation of Rad51. Whereas PARP2 is dispensable for tolerance of cells to single stranded breaks or homologous recombination dysfunction, it is redundant with PARP1 in BER.
Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells.
BRCA1-BARD1 mutants with weakened RAD51 interactions show compromised DNA joint formation and impaired mediation of homologous recombination and DNA repair in cells; results identify a late role of BRCA1-BARD1 in homologous recombination, an attribute of the tumour suppressor complex that could be targeted in cancer therapy
Our data suggest that in both BRCA1-mutant and BRCA1-wild-type TNBCs, CSCs are relatively resistant to PARP inhibition. This resistance is mediated by RAD51, suggesting that strategies aimed at targeting RAD51 may increase the therapeutic efficacy of PARPi
Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes.
RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
Describe and demonstrate a model showing loss of RAD51 leads to Fanconi anemia-like symptoms in zebrafish.
Although the presence of RAD51 protein provides essential support for the action of DMC1, these results show no significant effect of the absence of RAD51 strand-exchange activity on meiotic crossing-over rates or patterns in different chromosomal regions or across the whole genome of Arabidopsis, strongly supporting the argument that DMC1 catalyses repair of all meiotic DNA breaks, not only non-sister cross-overs.
The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
RAD51 forms a protein complex with AtRAD51C-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.
Our data demonstrate that RAD51 plays a supporting role for DMC1 in meiotic recombination in the flowering plant, Arabidopsis.
The present study demonstrates for the first time the involvement of a host RAD51 protein in mungbean yellow mosaic India virus replication.
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1, while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51
AtRAD51 is required to ensure the fidelity of homologous recombination during interchromosomal exchanges. It may also be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.
Study provides the molecular evidence showing that the BRCA2-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.
results show that loss of RAD51 caused hypersensitivity to the double-strand break-inducing agent bleomycin in P. patens but not Arabidopsis; data show importance of RAD51 for viability is independent of taxonomic position or complexity of an organism
RAD51 plays a critical role in maintaining chromosome integrity and mitochondrial activity during porcine oocyte maturation.
The complete cDNA sequences of the pig RAD51, RAD52, and RAD54 genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination.
Rad51 negatively regulates Netrin-1 signaling by modulating the expression of Unc5s in developing motor cortex.
RT-PCR and immunobloting data show that inhibitory effect of sodium butyrate takes place at the level of Rad51 and XRCC5 gene transcription and the content of Rad51 and Ku80 proteins.
Data show that the expression of miR-193b-3p and Rad51 was altered in in response to low-dose irradiation (LDIR) exposure.
The anti-recombinase activity of BLM is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination.
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 were recruited to these sites. H2AX was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX foci formation and DSB repair, whereas H2AX was barely stabilized in response to secondary DSBs, in which gammaH2AX foci were small and DSBs were not efficiently repaired
HOP2-MND1 enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
Rad51 repaired DNA damage.
An antimorphic mRad51 mutation, when present in heterozygous condition over wild-type, displays defects in non-replication-associated DNA repair and not in replication-associated repair.
BRCA2-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions.
increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2-mediated Rad51 polymerization
Results suggest that cellular levels of Brca2 and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53, which permits cell growth
FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
HELQ interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the Fanconi anaemia pathway to promote efficient homologous recombination at damaged replication forks
RAD51 recombinase inhibitor overcomes imatinib-resistance in chronic myeloid leukaemia.
activated Akt1 in Brca1-deficient cells impairs Chk1 nuclear localization and subsequently disrupts interaction of Chk1 and Rad51 leading to homologous recombination defects.
The control of protein levels of Rad51 in mouse embryonic stem cells and mouse embryo fibroblasts, was investigated.
The RAD51 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability.
a novel functional connection between PML and the homologous recombination-mediated repair machinery
Brca2 and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 predisposes to genome instability.
Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
By promoting CtIP-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Rad51 has a role at the replication fork protecting DNA from Mre11-dependent degradation.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
BRCA1/BRCA2-containing complex, subunit 5
, DNA repair protein RAD51 homolog 1
, RAD51 homolog A
, RecA, E. coli, homolog of
, RecA-like protein
, recombination protein A
, RAD51 homolog (RecA homolog, E. coli)
, homolog to S.cerevisiae
, RAD51 homolog
, DNA repair protein RAD51
, DNA repair protein RAD51 homolog A
, RAD51 homolog (RecA homolog)
, DNA repair protein RAD51-like 1