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calcineurin, upon activation by Ca(2 (zeige CA2 Antikörper)+)-calmodulin, cooperates with other factors to negatively regulate Egf receptor (zeige EGFR Antikörper) signaling at the level of sprouty and the GTPase-activating protein (zeige RASA1 Antikörper) Gap1
surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2.
this stusy demonstrates that male mice lacking Ppp3cc or Ppp3r2 genes (knockout mice) are infertile, with reduced sperm motility owing to an inflexible midpiece.
we report that calcineurin subunit B interacted with TLR4 (zeige TLR4 Antikörper), which in turn led to phosphorylaiton of IRF3 (zeige IRF3 Antikörper) and secretion of IFN-beta (zeige IFNB1 Antikörper)
The CnB could be of use as a prophylactic adjuvant as it is a human-derived safe agent and has immune-modulating effects that promote the control of cancer and infectious diseases.
Mice with genetic deletion of the calcineurin Abeta (zeige APP Antikörper) gene had a marked decrease in type II Na/Pi mRNA levels and remarkably did not show the expected increase in type II Na/Pi mRNA levels after the challenge of a low-Pi diet
By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo.
calcineurin-mediated skeletal muscle reprogramming induces the expression of several transcription regulators that coordinate changes in the expression of genes for lipid and glucose metabolism
These results suggest that calcineurin-dependent dephosphorylation plays an important role in the mechanisms of action of antidepressants, providing a new starting point for developing improved therapeutic treatments for depression.
Together, these findings reveal a previously unknown mechanism for the control of emotional memory that depends on CaN and Zif268 (zeige EGR1 Antikörper).
Deactivation of calcineurin/NFAT (zeige NFATC1 Antikörper) pathway-induced pathological hypertrophy is a preferential mechanism by which exercise training leads to the cardiac anti-remodelling effect in heart failure.
Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium- dependent, calmodulin-stimulated protein phosphatase (By similarity).
, calcineurin B
, calcineurin subunit B type 1
, protein phosphatase 2B regulatory subunit 1
, protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
, protein phosphatase 3 regulatory subunit B alpha
, PP2B beta 2
, calcineurin B subunit
, calcineurin subunit B type 2
, protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)
, protein phosphatase 2B regulatory subunit 2
, protein phosphatase 3 regulatory subunit B beta isoform