anti-Human Caspase 1 Antikörper für Immunohistochemistry

Recommended Caspase 1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Caspase 1 (CASP1) Antikörper
  • ICE
  • IL1BC
  • P45
  • Il1bc
  • Ice
  • CASP1
  • CG5370
  • DCP-1
  • DCP1
  • Dcp1
  • Dmel\\CG5370
  • ccp1
  • dcp-1
  • dcp1
  • l(2)01862
  • l(2)02132
  • caspase 1
  • caspase 1, apoptosis-related cysteine peptidase
  • caspase 4, apoptosis-related cysteine peptidase
  • Death caspase-1
  • caspase-1
  • caspase
  • caspase recruitment domain-containing protein 16
  • caspase 4
  • CASP1
  • Casp1
  • CASP4
  • Dcp-1
  • Caspase1
  • LOC5564196
  • LOC451519
Epitop
AA 1-100
35
16
12
11
10
10
9
9
7
7
6
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
258
96
75
8
2
2
2
1
1
1
1
1
1
Wirt
Maus
250
36
8
2
Klonalität
Monoklonal
Konjugat
Dieser Caspase 1 Antikörper ist unkonjugiert
23
16
8
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
266
160
117
76
32
26
18
15
7
5
3
3
1
Optionen
Hersteller
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Produktnummer ABIN393212
$ 461.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
15.576219 ABIN3183664 ELISA IHC WB Rabbit IgG Ser197 Anmelden zum Anzeigen Polyclonal 0
15.576219 ABIN3181758 ELISA IHC WB Rabbit IgG Asp210, cleaved Anmelden zum Anzeigen Polyclonal 0
15.576219 ABIN3021171 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.971891 ABIN461890 ELISA IHC IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
12.971891 ABIN6260470 ELISA ICC IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.971891 ABIN461892 ELISA IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN3182631 ELISA IHC WB Rabbit IgG pSer376 Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN3181759 ELISA IHC Rabbit IgG Met211, cleaved Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN5617521 ELISA IHC WB Rabbit IgG Ser376 Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN5619047 IHC WB Rabbit Center Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN5619046 IHC IP WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN5619048 IHC WB Rabbit Center Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN2135441 IHC ELISA WB Rabbit IgG Asp210 Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN2135442 IHC ELISA Rabbit IgG Asp210 Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN2135444 IHC ELISA WB Rabbit IgG pSer376 Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN2135436 IHC ELISA WB Biotin Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN2135434 IHC ELISA WB HRP Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN2135435 IHC ELISA WB FITC Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.576219 ABIN2135440 IHC ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
10 ABIN1858235 ICC IHC WB Rabbit IgG AA 120-297 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Caspase 1 (CASP1) Antikörper
Epitop AA 1-100
(35), (16), (12), (11), (10), (10), (9), (9), (7), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(258), (96), (75), (8), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Wirt Maus
(250), (36), (8), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser Caspase 1 Antikörper ist unkonjugiert
(23), (16), (8), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(266), (160), (117), (76), (32), (26), (18), (15), (7), (5), (3), (3), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-Caspase 1 Antikörper

Target Details Caspase 1 Anwendungsinformationen Handhabung Referenzen für anti-Caspase 1 Antikörper (ABIN393212) Bilder
Spezifität CASP1 (AAH62327, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Kreuzreaktivität (Details) Human: ~~ Positive
Reinigung This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: CASP1 (AAH62327, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon 3D2
Isotyp IgG2a kappa
Plasmids, Primers & others

Target Details Caspase 1

Produktdetails anti-Caspase 1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-Caspase 1 Antikörper (ABIN393212) Bilder zurück nach oben
Antigen
Andere Bezeichnung CASP1 (CASP1 Antibody Abstract)
Hintergrund

Other Names: Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, CASP1, IL1BC, IL1BCE

Gene Description: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Gene Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq

Molekulargewicht 45159 DA
Gen-ID 834
NCBI Accession NP_001214, NP_001244047, NP_001244048, NP_150634, NP_150635, NP_150636, NP_150637
UniProt P29466
Pathways Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity

Anwendungsinformationen

Produktdetails anti-Caspase 1 Antikörper Target Details Caspase 1 Handhabung Referenzen für anti-Caspase 1 Antikörper (ABIN393212) Bilder zurück nach oben
Applikations-hinweise ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Kommentare

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-Caspase 1 Antikörper Target Details Caspase 1 Anwendungsinformationen Referenzen für anti-Caspase 1 Antikörper (ABIN393212) Bilder zurück nach oben
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months

Referenzen für anti-Caspase 1 Antikörper (ABIN393212)

Produktdetails anti-Caspase 1 Antikörper Target Details Caspase 1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, 2010

Wang, Fu, Xie, Wang, Chu, Wang, Shen, Wang, Wang, Sun, Lei, Yang, Wu, Foo, Liu, Jin, Huang: "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." in: Journal of human genetics, Vol. 55, Issue 8, pp. 490-4, 2010

Kim, Park, Kim, Lee, Lim, Song, Yoo, Lee: "Mutational analysis of caspase genes in prostate carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 118, Issue 4, pp. 308-12, 2010

Weigert, Cremer, Schmidt, von Knethen, Angioni, Geisslinger, Brüne: "Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells." in: Blood, Vol. 115, Issue 17, pp. 3531-40, 2010

Bilder

Produktdetails anti-Caspase 1 Antikörper Target Details Caspase 1 Anwendungsinformationen Handhabung Referenzen für anti-Caspase 1 Antikörper (ABIN393212) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Immunoperoxidase of monoclonal antibody to CASP1 on formalin-fixed paraffin-embedded ...
Immunohistochemistry (IHC) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) anti-Caspase 1 (CASP1) (AA 1-100) antibody (Image 2)
Western Blotting (WB) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Immunohistochemistry (IHC) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Immunoperoxidase of monoclonal antibody to CASP1 on formalin-fixed paraffin-embedded ...
ELISA image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Detection limit for recombinant GST tagged CASP1 is approximately 0.1ng/ml as a captu...