TRKA Antikörper (AA 33-423)
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- Target Alle TRKA (NTRK1) Antikörper anzeigen
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
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Bindungsspezifität
- AA 33-423
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TRKA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
- Klon
- 6B2
- Isotyp
- IgG1
- Top Product
- Discover our top product NTRK1 Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, (2008) (PubMed).
: "Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells." in: DNA repair, Vol. 7, Issue 10, pp. 1757-64, (2008) (PubMed).
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TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, (2008) (PubMed).
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- Target
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- Andere Bezeichnung
- TrkA (NTRK1 Produkte)
- Synonyme
- MTC antikoerper, TRK antikoerper, TRK1 antikoerper, TRKA antikoerper, Trk-A antikoerper, p140-TrkA antikoerper, CDHF12 antikoerper, CDHR16 antikoerper, HSCR1 antikoerper, MEN2A antikoerper, MEN2B antikoerper, MTC1 antikoerper, PTC antikoerper, RET-ELE1 antikoerper, RET51 antikoerper, Trk antikoerper, C80751 antikoerper, Tkr antikoerper, TrkA antikoerper, trk antikoerper, trka antikoerper, CTRKA antikoerper, trkA antikoerper, neurotrophic receptor tyrosine kinase 1 antikoerper, ret proto-oncogene antikoerper, neurotrophic tyrosine kinase, receptor, type 1 antikoerper, NTRK1 antikoerper, RET antikoerper, Ntrk1 antikoerper, ntrk1 antikoerper
- Hintergrund
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Description: TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Aliases: NTRK1, MTC, TRK, TRK1
- Molekulargewicht
- 87.4 kDa
- Gen-ID
- 4914
- HGNC
- 4914
- Pathways
- RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process
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