AXL Antikörper (Extracellular)

Produktnummer ABIN965630

Produktdetails anti-AXL Antikörper

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Bindungsspezifität: Extracellular

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AXL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.

Klon: 7E10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-AXL Antikörper (ABIN965630)

Green, Ikram, Vyas, Patel, Proby, Ghali, Leigh, OToole, Storey: "Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours." in: British journal of cancer, Vol. 94, Issue 10, pp. 1446-51, (2006) (PubMed).

Vajkoczy, Knyazev, Kunkel, Capelle, Behrndt, von Tengg-Kobligk, Kiessling, Eichelsbacher, Essig, Read, Erber, Ullrich: "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 15, pp. 5799-804, (2006) (PubMed).

Details zu AXL

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Andere Bezeichnung: AXL (AXL Produkte)

Synonyme: JTK11 antikoerper, UFO antikoerper, AI323647 antikoerper, Ark antikoerper, Tyro7 antikoerper, Ufo antikoerper, AXL receptor tyrosine kinase antikoerper, Axl receptor tyrosine kinase antikoerper, AXL antikoerper, Axl antikoerper

Hintergrund: AXL receptor tyrosine kinase, also known as UFO, JTK11. Entrez Protein NP_001690. It is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: UFO, JTK11

Molekulargewicht: 97.4kDa

Gen-ID: 558

Pathways: RTK Signalweg, Cellular Response to Molecule of Bacterial Origin