Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

AXL Antikörper (AA 312-447)

AXL Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7174056
  • Target Alle AXL Antikörper anzeigen
    AXL (AXL Receptor tyrosine Kinase (AXL))
    Bindungsspezifität
    • 20
    • 20
    • 20
    • 16
    • 15
    • 12
    • 11
    • 9
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 312-447
    Reaktivität
    • 136
    • 62
    • 55
    • 6
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    Human
    Wirt
    • 123
    • 19
    • 3
    • 1
    Kaninchen
    Klonalität
    • 123
    • 23
    Polyklonal
    Konjugat
    • 59
    • 12
    • 11
    • 10
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser AXL Antikörper ist unkonjugiert
    Applikation
    • 118
    • 69
    • 37
    • 26
    • 26
    • 21
    • 15
    • 9
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Tyrosine-protein kinase receptor UFO protein (312-447AA)
    Isotyp
    IgG
    Top Product
    Discover our top product AXL Primärantikörper
  • Applikationshinweise
    Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    AXL (AXL Receptor tyrosine Kinase (AXL))
    Andere Bezeichnung
    AXL (AXL Produkte)
    Synonyme
    JTK11 antikoerper, UFO antikoerper, AI323647 antikoerper, Ark antikoerper, Tyro7 antikoerper, Ufo antikoerper, AXL receptor tyrosine kinase antikoerper, Axl receptor tyrosine kinase antikoerper, AXL antikoerper, Axl antikoerper
    Hintergrund

    Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

    Aliases: Adhesion related kinase antibody, AI323647 antibody, Ark antibody, Axl antibody, AXL oncogene antibody, AXL receptor tyrosine kinase antibody, AXL transforming gene antibody, AXL transforming sequence/gene antibody, EC 2.7.10.1 antibody, JTK11 antibody, Oncogene AXL antibody, Tyro7 antibody, Tyrosine protein kinase receptor UFO antibody, Tyrosine-protein kinase receptor UFO antibody, UFO antibody, UFO_HUMAN antibody

    UniProt
    P30530
    Pathways
    RTK Signalweg, Cellular Response to Molecule of Bacterial Origin
Sie sind hier: