LAT2 Antikörper (Cytoplasmic Domain) (PE)
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- Target Alle LAT2 Antikörper anzeigen
- LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))
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Bindungsspezifität
- AA 91-243, Cytoplasmic Domain
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser LAT2 Antikörper ist konjugiert mit PE
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Applikation
- Flow Cytometry (FACS)
- Spezifität
- The antibody NAP-07 reacts with an intracellular epitope of Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B lymphocytes, NK cells and myeloid cells.
- Kreuzreaktivität (Details)
- Mouse, Human, Other not tested
- Aufreinigung
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogen
- Recombinant cytoplasmic domain (aa 91-243) of human NTAL.
- Klon
- NAP-07
- Isotyp
- IgG1
- Top Product
- Discover our top product LAT2 Primärantikörper
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- Applikationshinweise
- Flow cytometry: Intracellular staining, recommended dilution: 1-5 μg/mL, positive tissue: RAJI human lymphoma cell line, RAMOS human lymphoma cell line.
- Kommentare
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.1 mg/mL
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
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Do not freeze.
Avoid prolonged exposure to light. - Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation." in: Blood, Vol. 104, Issue 1, pp. 207-14, (2004) (PubMed).
: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, (2004) (PubMed).
: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, (2002) (PubMed).
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NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation." in: Blood, Vol. 104, Issue 1, pp. 207-14, (2004) (PubMed).
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- Target
- LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))
- Andere Bezeichnung
- NTAL / LAB (LAT2 Produkte)
- Synonyme
- LAB antikoerper, NTAL antikoerper, WBSCR15 antikoerper, WBSCR5 antikoerper, WSCR5 antikoerper, LAT2 antikoerper, MGC139435 antikoerper, Ntal antikoerper, Wbscr5 antikoerper, AW125574 antikoerper, Wbscr15 antikoerper, linker for activation of T-cells family member 2 antikoerper, linker for activation of T cells family, member 2 antikoerper, LAT2 antikoerper, Lat2 antikoerper
- Hintergrund
- Linker for activation of T cells family member 2,NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.,LAB, LAT2
- Gen-ID
- 56743
- UniProt
- Q9JHL0
- Pathways
- Fc-epsilon Rezeptor Signalübertragung, BCR Signaling
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