LAT2 Antikörper (AA 196-212)

Produktnummer ABIN94442

Produktdetails anti-LAT2 Antikörper

Target: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Bindungsspezifität: AA 196-212

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: The antibody NAP-03 recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells.

Keine Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.

Klon: NAP-03

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, positive tissue: tonsil, germinal center.
Western blotting: Recommended dilution: 1-2 μg/mL, incubation 60 min, positive control: RAMOS human lymphoma cell line, non-reducing conditions, 12 % separating SDS-PAGE gel.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-LAT2 Antikörper (ABIN94442)

Brdicka, Imrich, Angelisová, Brdicková, Horváth, Spicka, Hilgert, Lusková, Dráber, Novák, Engels, Wienands, Simeoni, Osterreicher, Aguado, Malissen, Schraven, Horejsí: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, (2002) (PubMed).

Details zu LAT2

Target: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Andere Bezeichnung: NTAL / LAB (LAT2 Produkte)

Synonyme: LAB antikoerper, NTAL antikoerper, WBSCR15 antikoerper, WBSCR5 antikoerper, WSCR5 antikoerper, LAT2 antikoerper, MGC139435 antikoerper, Ntal antikoerper, Wbscr5 antikoerper, AW125574 antikoerper, Wbscr15 antikoerper, linker for activation of T-cells family member 2 antikoerper, linker for activation of T cells family, member 2 antikoerper, LAT2 antikoerper, Lat2 antikoerper

Hintergrund: Linker for activation of T cells family member 2,NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.,LAB, LAT2

Gen-ID: 7462

UniProt: Q9GZY6

Pathways: Fc-epsilon Rezeptor Signalübertragung, BCR Signaling