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LAT2 Antikörper (Linker For Activation of T Cells Family, Member 2) Cytoplasmic Domain Primary Antibody

LAT2 Reaktivität: Maus WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (1 reference)
Produktnummer ABIN125754
$417.45
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle LAT2 Antikörper anzeigen
    LAT2
    Bindungsspezifität
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 124-203, Cytoplasmic Domain
    Reaktivität
    • 66
    • 25
    • 17
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 56
    • 13
    • 7
    Kaninchen
    Klonalität
    • 63
    • 13
    Polyklonal
    Konjugat
    • 47
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LAT2 Antikörper ist unkonjugiert
    Applikation
    • 68
    • 34
    • 19
    • 17
    • 7
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
    Keine Kreuzreaktivität
    Human
    Kreuzreaktivität (Details)
    Mouse, Other species Not tested
    Aufreinigung
    Purified from rabbit serum by affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, (2004) (PubMed).

  • Target
    LAT2
    Andere Bezeichnung
    NTAL / LAB (LAT2 Produkte)
    Synonyme
    LAB, NTAL, WBSCR15, WBSCR5, WSCR5, LAT2, MGC139435, Ntal, Wbscr5, AW125574, Wbscr15, linker for activation of T-cells family member 2, linker for activation of T cells family, member 2, LAT2, Lat2
    Hintergrund
    NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, BCR Signaling
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