LAT2 Antikörper (Cytoplasmic Domain)

Produktnummer ABIN125754

Produktdetails anti-LAT2 Antikörper

Target: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Bindungsspezifität: AA 124-203, Cytoplasmic Domain

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.

Keine Kreuzreaktivität: Human

Kreuzreaktivität (Details): Mouse, Other species Not tested

Aufreinigung: Purified by ligand affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.

Anwendungsinformationen

Applikationshinweise: Western blotting: Recommended dilution: 1 μg/mL, positive control: murine spleen, non-reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-LAT2 Antikörper (ABIN125754)

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, (2004) (PubMed).

Details zu LAT2

Target: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Andere Bezeichnung: NTAL / LAB (LAT2 Produkte)

Synonyme: LAB antikoerper, NTAL antikoerper, WBSCR15 antikoerper, WBSCR5 antikoerper, WSCR5 antikoerper, LAT2 antikoerper, MGC139435 antikoerper, Ntal antikoerper, Wbscr5 antikoerper, AW125574 antikoerper, Wbscr15 antikoerper, linker for activation of T-cells family member 2 antikoerper, linker for activation of T cells family, member 2 antikoerper, LAT2 antikoerper, Lat2 antikoerper

Hintergrund: Linker for activation of T cells family member 2,NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.,LAB, LAT2

Gen-ID: 7462

UniProt: Q9GZY6

Pathways: Fc-epsilon Rezeptor Signalübertragung, BCR Signaling