Caspase 12 Antikörper (AA 201-300) (Alexa Fluor 488)
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- Target Alle Caspase 12 (CASP12) Antikörper anzeigen
- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
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Bindungsspezifität
- AA 201-300
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Reaktivität
- Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Caspase 12 Antikörper ist konjugiert mit Alexa Fluor 488
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from mouse Caspase 12
- Isotyp
- IgG
- Top Product
- Discover our top product CASP12 Primärantikörper
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- Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
- Andere Bezeichnung
- Caspase 12 (CASP12 Produkte)
- Synonyme
- Caspase-12 antikoerper, CASP-12 antikoerper, CASP12P1 antikoerper, caspase 12 antikoerper, caspase 12 (gene/pseudogene) antikoerper, Casp12 antikoerper, CASP12 antikoerper
- Hintergrund
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Synonyms: Caspase-12, CASP-12, Casp12
Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].
- Gen-ID
- 12364
- UniProt
- O08736
- Pathways
- Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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