ABL1 Antikörper (Alexa Fluor 555)

Produktnummer ABIN885838

Produktdetails anti-ABL1 Antikörper (Alexa Fluor 555)

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL1 Antikörper ist konjugiert mit Alexa Fluor 555

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human c-Abl

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ABL1

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Andere Bezeichnung: C-Abl (ABL1 Produkte)

Synonyme: ABL antikoerper, JTK7 antikoerper, bcr/abl antikoerper, c-ABL antikoerper, p150 antikoerper, v-abl antikoerper, AI325092 antikoerper, Abl antikoerper, E430008G22Rik antikoerper, c-Abl antikoerper, ABL proto-oncogene 1, non-receptor tyrosine kinase antikoerper, c-abl oncogene 1, non-receptor tyrosine kinase antikoerper, Tyrosine-protein kinase abl-1 antikoerper, ABL1 antikoerper, Abl1 antikoerper, abl-1 antikoerper, abl1 antikoerper

Hintergrund:

Synonyms: Abelson Murine Leukemia Viral Oncogene Homolog 1, Abelson murine leukemia viral v abl oncogene homolog 1, Abl 1, ABL, Abl1, Abl protein, Abl1, Bcr/c abl oncogene protein, JTK 7, JTK7, p150, Proto oncogene tyrosine protein kinase ABL1, Transformation gene oncogene ABL, v abl Abelson murine leukemia viral oncogene homolog 1, v abl, ABL1_HUMAN.

Background: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

Gen-ID: 25

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism