ABL1 Produkte
(C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
Kategorien
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9\;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008].
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Ausgewählte ABL1 Kategorien
ABL1 Antikörper
High quality antibodies with extensive validation data.
ABL1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ABL1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene ABL1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (6)
Kat. Nr.
ABIN3020872
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p), DB
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN6241067
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Monkey, Mouse, Rat
Applikation
WB, ELISA, IF, ICC
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN6256686
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene ABL1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
- (3)
Kat. Nr.
ABIN6730567
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6975039
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380761
Menge
2 x 96 tests
Datenblatt
Datenblatt
Empfohlene ABL1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5570741
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5569840
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5569841
Menge
5 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren ABL1 Produkten
: "Defining the target and the effect of imatinib on the filarial c-Abl homologue." in: PLoS neglected tropical diseases, Vol. 11, Issue 7, pp. e0005690, (2017) (PubMed).: "A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy." in: The Analyst, Vol. 140, Issue 4, pp. 1207-14, (2015) (PubMed).
: "Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease." in: Redox biology, Vol. 2, pp. 82-90, (2015) (PubMed).
: "Altered expression of c-Abl in patients with epilepsy and in a rat model." in: Synapse (New York, N.Y.), Vol. 68, Issue 7, pp. 306-16, (2014) (PubMed).
: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." in: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).
: "Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway." in: Scientific reports, Vol. 4, pp. 6527, (2014) (PubMed).
: "Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons." in: The Journal of biological chemistry, Vol. 288, Issue 33, pp. 23725-39, (2013) (PubMed).
: "Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors." in: PLoS ONE, Vol. 7, Issue 10, pp. e45964, (2012) (PubMed).
: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).
: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).
Synonyme und alternative Namen zu ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), c-abl oncogene 1, non-receptor tyrosine kinase (Abl1), ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), Tyrosine-protein kinase abl-1 (abl-1), c-abl oncogene 1, non-receptor tyrosine kinase (abl1), ABL, Abl, AI325092, bcr/abl, c-ABL, c-Abl, E430008G22Rik, JTK7, p150, v-ablBezeichner auf Proteinebene für ABL1
- Abelson tyrosine-protein kinase 1
- bcr/c-abl oncogene protein
- c-abl oncogene 1, receptor tyrosine kinase
- proto-oncogene c-Abl
- proto-oncogene tyrosine-protein kinase ABL1
- tyrosine-protein kinase ABL1
- v-abl Abelson murine leukemia viral oncogene homolog 1
- Abelson murine leukemia oncogene
- abelson murine leukemia viral oncogene homolog 1
- p150
- v-abl Abelson murine leukemia oncogene 1
- Abelson murine leukemia viral (v-abl) oncogene homolog 1
- v-abl Abelson murine leukemia viral oncogene 1
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